Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE However, there is little information on the possible impact of the HPV genotype and p16 immunostaining on the clinicopathological features or their prognostic value in cervical carcinoma. 31492932

2020

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE Immunohistochemical expression of p16 in ovarian tumors can guide the diagnosis of metastasis from HPV-related cervical cancer, but p16 positivity is nonspecific. 31014281

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Ki-67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions. 31423197

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE Association of p16 (CDKN2A) polymorphisms with the development of HPV16-related precancerous lesions and cervical cancer in the Greek population. 29168898

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE We aimed to investigate the expression and clinical significance of cyclin-dependent kinase inhibitor 2A (P16<sup>INK4A</sup>), sex determining region Y-box 2 (SOX2), and Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1) in cervical cancer treated with radiotherapy and cervical cell line models. 30150594

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE The mRNA expression levels of OVCA1, cyclin D1 and p16 in cervical cancer and normal cervix cells were detected using real-time polymerase chain reaction. 28521400

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Role of p16 testing in cervical cancer screening among HIV-infected women. 29023464

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE By overlapping these dysregulated genes, we found that three genes, including CDKN2A, IL1R2 and RFC4, were not only changed in HSIL, but also significantly changed in SCC, indicating that their dysregulation may contribute to cervical cancer development. 28341182

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE HNRNPA1 (92%) and p16 (91%) presented the two highest diagnostic accuracies for cervical carcinoma, which were superior to those of SRSF3 (75%), SRSF1-HMws (72%), CEA (72%), SCCA (59%), and SRSF1-Total (55%). 27984373

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE The methylation of the p16 gene promoter could significantly reduce p16 expression, losing its tumor suppressor activity and promoting the development of cervical cancer. 28617556

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE P16INK4a hypermethylation was significantly associated with the increased risk of LSIL, HSIL and CC, with the pooled ORs of 3.26 (95% CI: 1.86-5.71), 5.80 (95% CI: 3.80-8.84) and 12.17 (95% CI: 5.86-25.27), respectively. 27669738

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 PosttranslationalModification BEFREE Promoter CpG island hypermethylation of p16 gene was detected in 20.9% tissue samples of cervical carcinoma. 28453456

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE The deletion frequency of P16 and RB1 increased significantly with CACX progression. 27458253

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE To conduct a comprehensive mapping of the genomic DNA methylation in CDKN2A, which codes for the p16(INK4A) and p14(ARF) proteins, and 14 of the most promising DNA methylation marker candidates previously reported to be associated with progression of low-grade cervical intraepithelial neoplasia (CIN1) to cervical cancer. 27401842

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE Correlation between methylation status of p16 gene and poor menstrual hygiene was significant (p=0.006), high parity cases showed methylation of p16 gene (p=0.031) with increased risk up to 1.86 times for cervical cancer and smoking was a strong risk factor associated with cervical cancer. 27644676

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE The isolated and combined analysis of CDKN2A/p16 mRNA to CC diagnosis was done with promising results. 27761872

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE Under those conditions, p16INK4a expression was always elevated during the late stage of limited cell lifespan, suggesting that cervical epithelial cells possess an intrinsic property of uniquely stringent activation of p16INK4a, which may offer an explanation for the rarity of HPV-negative cervical cancer. 27344169

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE Methylation of the p16(INK4a) gene occurs early in the development of cervical cancer. 25579180

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Moreover, p16 protein was associated with CIN grade and lymph node metastases in cervical cancer (all P<0.05); survivin protein was also related with clinical stages, CIN grade and lymph node metastases (all P<0.05); the p16 and survivin expressions were positively correlated with cervical cancer (r=0.854, P<0.001), and associated with poor prognosis of cervical cancer. 25910412

2015

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 PosttranslationalModification BEFREE The promoter methylation of DAPK1, FHIT, MGMT, and CDKN2A was investigated by using a methylation-specific polymerase chain reaction in 53 specimens of cervical cancer (42 squamous cell carcinoma, 11 adenocarcinoma), 22 specimens of intraepithelial neoplasia tissues, and 24 control normal cervical tissue specimens. 23494221

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE The role of p16INK4A expression in uterine cervix cancer is well established. 25605180

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE The results revealed that p16(ink4a) was overexpressed in the cervical cancer and precancerous lesions (P<0.05). 24714974

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 AlteredExpression BEFREE Immunohistochemistry of p16INK4A staining shows nil (0/25) expression in the cervicitis patients, 72% (18/25) in CIN patients and 100% (25/25) in cervical carcinoma. 25361681

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE 1) To analyze the expression of Ki-67, p53 and p16(INK4a) in cervical cancer, 2) to correlate the relative expression of these proteins as well as clinical parameters with the stage of disease, and 3) to determine the HPV DNA prevalence and subtype distribution. 23505442

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. 24046371

2013