Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE Sustained interaction of advanced glycation end products (AGEs) with their receptor RAGE and subsequent signaling plays an important role in the development of diabetic complications. 23721855

2013

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE The receptor for advanced glycation end products (RAGE) plays an important role in the pathogenesis of diabetic complications. 23432638

2013

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE The receptor for advanced glycation end products (RAGE) is a multiligand cell surface macromolecule that plays a central role in the etiology of diabetes complications, inflammation, and neurodegeneration. 22194616

2012

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in inflammatory disorders, tumor outgrowth, diabetic complications and Alzheimer's disease (AD). 22571615

2012

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE Interaction of receptor for advanced glycation end products (RAGE) with advanced glycation end products (AGEs) is an important pathogenic mechanism of diabetic complications. 20040351

2010

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE Engagement of the receptor for advanced glycation end products (RAGE) with advanced glycation end products and subsequent signaling play an important role in the development of diabetic complications. 19766904

2009

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE The receptor for advanced glycation end products (RAGE) plays an important role in the pathogenesis of diabetic complications. 19542745

2009

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 AlteredExpression BEFREE Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. 18952609

2008

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 AlteredExpression LHGDN Severity of diabetic microvascular complications is associated with a low soluble RAGE level. 18701333

2008

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 GeneticVariation BEFREE The aim of our study was therefore to explore whether polymorphisms (TNF -308 G-->A, LTA T60N C-->A and AGER -374 T-->A) in these genes alone or together (as haplotypes) increased the risk for diabetic complications. 18575614

2008

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 GeneticVariation LHGDN The aim of our study was therefore to explore whether polymorphisms (TNF -308 G-->A, LTA T60N C-->A and AGER -374 T-->A) in these genes alone or together (as haplotypes) increased the risk for diabetic complications. 18575614

2008

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE Our hypothesis is that RAGE may be involved in the evolution of insulin resistance in addition to mediating glucotoxic complications of diabetes mellitus. 16305072

2005

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 GeneticVariation BEFREE Genetic variability in the RAGE gene: possible implications for nutrigenetics, nutrigenomics, and understanding the susceptibility to diabetic complications. 15937999

2005

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 Biomarker BEFREE RAGE and its ligands: a lasting memory in diabetic complications? 16305050

2004