Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Tolrestat and epalrestat have been characterized as noncompetitive inhibitors of aldo-ketone reductase 1B1 (AKR1B1), a leading drug target for the treatment of type 2 diabetes complications. 31573681

2020

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE Key findings are that (a) low doses of Nasonia venom elevate sorbitol levels in human renal mesangial cells (HRMCs) without changing glucose or fructose levels; (b) venom is a much more potent inducer of sorbitol elevation than glucose; (c) low venom doses significantly alter expression of genes involved in sterol and alcohol metabolism, transcriptional regulation, and chemical/stimulus response; (d) although venom treatment does not alter expression of the key sorbitol pathway gene aldose reductase (AR); (e) venom elevates expression of a related gene implicated in diabetes complications (AKR1C3) as well as the fructose metabolic gene (GFPT2). 30831148

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE To develop multifunctional aldose reductase (AKR1B1) inhibitors for anti-diabetic complications, a novel series of 2-phenoxypyrido[3,2-<i>b</i>]pyrazin-3(4<i>H</i>)-one derivatives were designed and synthesised. 31347930

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Humans exhibit three members of the AKR1B subfamily: AKR1B1 (aldose reductase, participates in diabetes complications), AKR1B10 (overexpressed in several cancer types), and the recently described AKR1B15. 31028727

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR), a member of aldo-keto reductase family, is the rate-limiting enzyme in the polyol pathway, and is known to play a key role in the pathogenesis of diabetic complications. 30707979

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Subtle involvement of ALR2 in invoking various pathways of diabetic complications has caused an increase in attention towards the identification of novel aldose reductase inhibitors (ARIs). 30551523

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE Inhibition of AR activity thus might be a potential approach for the management of diabetic complications. 29792152

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR) is associated with the onset of diabetic complications. 31155561

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AKR1B1) has been considered as a significant target for designing drugs to counteract the development of diabetic complications. 29671687

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Several ALR2 inhibitors with a promising pre-clinical ability to address diabetic complications and inflammatory diseases are being developed during the observed timeframe. 30760060

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Compound (3e) was selective 96 fold towards ALR2 which is closely related to serious diabetic complications. 31221611

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR), α-amylase, and α-glycosidase are vital enzymes to prevent diabetic complications. 31135076

2019

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Investigation of the cause of BmAR downregulation in the q-l<sup>p</sup> mutant could contribute to revealing the function of AR in insects and offers a new method of identifying AR inhibitors for the treatment of diabetic complications. 29730425

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose Reductase (AR), a polyol pathway enzyme that mediates diabetic complications is implicated in tumour development and progression. 30062975

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE The synthetic ARIs are often associated with deleterious side effects and medicinal and edible plants, containing compounds with aldose reductase inhibitory activity, could be useful for prevention and therapy of diabetic complications. 29427593

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Functional compounds with antioxidant and AR inhibitory activities have been recognized as an important strategy in the prevention and treatment of diabetic complications, and the search for tyrosinase inhibitors is important for the treatment of hyperpigmentation, development of skin-whitening agents, and use as preservatives in the food industry. 29513344

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE The study stands out as a systematic attempt to generate aldose reductase differential inhibitors (ARDIs) intended to target long-term diabetic complications while leaving unaltered the detoxifying role of the enzyme. 30122369

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE The formation of advanced glycation end-products (AGE) and aldose reductase activity have been implicated in the development of diabetic complications. 29230690

2018

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 AlteredExpression BEFREE Oxidative stress and aldose reductase activity have been implicated in the development of diabetic complications. 28484711

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. 28217947

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. 28512639

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (ALR2) inhibition is the most legitimate approach for the management of diabetic complications. 28399135

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena. 28856935

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 GeneticVariation BEFREE The N-(aroyl)-N-(arylmethyloxy)-α-alanines are a promising starting point for the development of new ALR2 selective drugs with the aim of delaying the onset of diabetic complications. 28392277

2017

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE This work represents a promising matrix for developing new potential therapeutic candidates for prevention of diabetic complications through targeting aldose reductase enzyme.[Formula: see text]. 29098865

2017