Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 PosttranslationalModification BEFREE RESULTS The incidence of FHIT and p16 methylation in serum from the liver cancer group was 51.8% and 67.9%, respectively. 30773529

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 AlteredExpression BEFREE The p16 protein expressions in liver cancer and para-carcinoma tissues were detected via immunohistochemistry (IHC), and the correlations of p16 positive expression with ultrasound parameters were also analyzed. 30509095

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker BEFREE These results are significant because they suggest that nucleolar p14ARF can be used as early prognostic marker in chronic liver disease to reliably identify patients with high risk for developing liver cancer. 29228217

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker CTD_human Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. 27064257

2016

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker BEFREE Yet Bmi1 functions independent of Ink4A/Arf repression in liver cancer development. 19934271

2009

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 AlteredExpression BEFREE Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. 16317707

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker CTD_human Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. 16317707

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker RGD Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. 16317707

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker CTD_human Abnormalities of the ARF-p53 pathway in primary angiosarcomas of the liver. 12378512

2002

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker RGD De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats. 12359353

2002

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker RGD Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma. 11301474

2001

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 GeneticVariation BEFREE The purpose of the current investigation was to define the prevalence of genetic alterations in p16 and beta-catenin in NNK-induced rat liver cancer to determine if the molecular mechanisms seen in human tumors are the same in this animal model. 11238187

2001

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 PosttranslationalModification BEFREE Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. 9892188

1999

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 Biomarker BEFREE Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers. 9873831

1998

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.590 PosttranslationalModification BEFREE Infrequent alterations of the p16INK4A gene in liver cancer. 8760583

1996