Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475

2018

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation BEFREE The most prevalent mutations among patients with PC are c.1621A>C (rs3822214) in KIT, c.38G>C (rs112445441) in KRAS and c.733G>A (rs28934575) in TP53 genes. 29650325

2018

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker BEFREE MALAT1 knockdown inhibited proliferation and migration and facilitated apoptosis by upregulating miR-1 and downregulating KRAS in androgen receptor-negative PCa cells, providing a new insight into the molecular basis of MALAT1 and a potential biomarker or therapeutic target for suppressing castration-resistant PC. 29942138

2018

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 AlteredExpression BEFREE Low expression of microRNA-30c promotes prostate cancer cells invasion involved in downregulation of KRAS protein. 28693177

2017

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation BEFREE It is increasingly clear that there are molecularly distinct subtypes of various common cancers, with different therapeutic approaches required for each subtype, for example, the use of the monoclonal antibodies (trastuzumab and cetuximab) in HER2-positive breast cancer and wild-type KRAS colorectal cancer; tyrosine kinase inhibitors (imatinib, gefitinib, erlotinib and crizotinib) in chronic myeloid leukaemia, gastrointestinal stromal tumours and non-small-cell lung cancer and intracellular agents (vemurafenib and olaparib) in metastatic malignant melanoma and ovarian, breast and prostate cancer. 24789362

2015

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker BEFREE KRAS NF-κB is involved in the development of zinc resistance and reduced curability in prostate cancer. 24927480

2014

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker BEFREE In this study, the mutation status of specified exons of the EGFR and KRAS genes was profiled in patients with prostate cancer (PCa). 24595526

2014

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation BEFREE We demonstrated that the PS method detected more K-Ras mutations in codons 12 and 13 of FFPE prostate cancer samples from Chinese patients than the traditional SS method. 22732508

2012

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation BEFREE Prostate cancer is a common malignancy that develops by structural mutation(s) and/or other genetic alterations in specific genes.The G to T transversions in codon 12 and C to T transitions in codon 13 of KRAS proto-oncogene are predominant point mutations that occur in about 20% of different cancers in human. 21607617

2012

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker BEFREE Using an integrative genomics approach called amplification breakpoint ranking and assembly analysis, we nominated KRAS as a gene fusion with the ubiquitin-conjugating enzyme UBE2L3 in the DU145 cell line, originally derived from prostate cancer metastasis to the brain. 22140652

2011

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 AlteredExpression BEFREE These findings suggest that miR-143 plays an important role in prostate cancer proliferation, migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway, which provides a potential development of a new approach for the treatment of prostate cancer. 21197560

2011

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation BEFREE KRAS oncogene rearrangements and gene fusions: unexpected rare encounters in late-stage prostate cancers. 22586312

2011

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 GeneticVariation BEFREE Mutations in the three closely related RAS genes, HRAS, KRAS, and NRAS are among the most common mutations found in human cancer; reaching 50% in some types of cancer, such as colorectal carcinoma, and 10% in prostate cancers. 15781617

2005

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.600 Biomarker MGD