Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE To explore the role of RNASEL gene polymorphisms in prostate cancer, we carried out the present meta-analysis. 31686670

2019

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Our present study showed evidence that RNASEL 1623A>C polymorphism is related to PCa risk, especially in African descendants. 30790337

2019

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE As a result, the CCND1-RNASEL-CDKN1A-TP73-MDM2-UBE2I axis was identified as a bottleneck in the miRNA-mediated gene expression regulatory network of PCa according to network topological analysis. 29467540

2018

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE To address this issue, we performed a meta-analysis to evaluate the association between RNASEL -1385G/A polymorphism and prostate cancer risk. 29317837

2018

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE In conclusion, the RNASEL Arg462Gln polymorphism may contribute to the risk of developing prostate cancer in African descendants and Hispanic Caucasians. 29088852

2017

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE We show that mutations in RNase L found in HPC patients may promote prostate cancer by increasing expression of AR-responsive genes and cell motility and identify novel roles of RNase L as a prostate cancer susceptibility gene. 28257035

2017

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker CTD_human Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk. 27318894

2016

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Here we report that ablation of RNase L in human prostate cancer PC3 cells by CRISPR/Cas9 gene editing technology enhanced cell migration as determined both by transwell assays and scratch wound healing assays. 26517238

2015

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk patients. 26251261

2015

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL. 26236721

2015

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a Hispanic population. 24224612

2014

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781

2013

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE We show an association between RNASEL SNP rs12757998 and outcome after radiation therapy for prostate cancer. 23382116

2013

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Predictive value in the analysis of RNASEL genotypes in relation to prostate cancer. 22083266

2012

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE To answer questions regarding the prevalence of XMRV in Iranian patients with prostate cancer and its association with the RNASEL R462Q polymorphism, we here investigated a series of cases in Kerman, in the Southeast of Iran, and sought to verify the association with the R462Q using Real Time PCR Method. 23098452

2012

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE In conclusion, we found that these RNASEL polymorphisms were not related to overall PCa risk, especially in Caucasians. 21656378

2012

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE RNASEL variants having the 541D haplotype likely have a greater ability to defend against infections by viruses, thus the loss of this activity may be associated with the development of prostate cancer. 22513284

2012

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE We report here the prevalence of XMRV in a population with well-defined prostate cancers and RNase L polymorphism. 21573232

2011

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Two RNASEL SNPs were associated with overall increases in prostate cancer risk (OR = 1.13 for each variant allele of rs12723593; OR = 1.88 for any variant allele of rs56250729). 21360564

2011

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Xenotropic murine leukemia virus (MLV)-related virus (XMRV) was initially identified in prostate cancer (PCa) tissue, particularly in the prostatic stromal fibroblasts, of patients homozygous for the RNASEL R462Q mutation. 21447170

2011

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE There are questions regarding the prevalence of xenotropic murine leukemia virus-related virus (XMRV) in patients with prostate cancer and its association with the RNASEL R462Q polymorphism. 20936978

2010

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE We therefore investigated the association between variation in RNASEL and prostate cancer risk and progression in a study of 1286 cases and 1264 controls nested within the prospective Physicians' Health Study. 20576793

2010

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE The observation that a mutation predicted to completely inactivate RNASEL protein was not associated with prostate cancer, but that a missense variant was associated, suggests that the effect is due to either partial inactivation of the protein, and/or acquisition of a new protein activity. 20564318

2010

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Xenotropic murine leukemia virus-related virus (XMRV) is a new human retrovirus originally identified in prostate cancer patients with a deficiency in the antiviral enzyme RNase L. XMRV has been detected with varying frequencies in cases of prostate cancer and chronic fatigue syndrome (CFS), as well as in a small proportion of healthy individuals. 20717743

2010

Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Recently, the Xenotropic Murine Leukemia Virus-related gammaretrovirus (XMRV) was identified in prostate tissue with a high prevalence observed in prostate cancer (PC) patients homozygous for the glutamine variant of the RNASEL protein (462Q/Q). 20576103

2010