Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE In contrast, none of the endometrioid and serous endometrial carcinomas expressed ZEB1, while 6% and 36% of endometrioid and 11% and 25% of serous carcinomas focally expressed ZEB2 and TWIST1, respectively. 30739164

2019

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE In clinical samples, ZEB1 positively correlates with HDGF expression, and co-expression of ZEB1 and HDGF promotes the pathogenesis of EC. 31815037

2019

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE The role of WWOX tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-VIM expression in endometrial cancer. 25892250

2015

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE Quantitative methylation studies dismissed CDH1 promoter hypermethylation as the mechanism responsible for this change in gene expression, while immunohistochemistry revealed that the E-cadherin repressor ZEB1 was frequently overexpressed (62%) in undifferentiated endometrial carcinomas. 23743934

2013

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE Here, we report that mutant p53 exerts oncogenic functions and promotes EMT in endometrial cancer (EC) by directly binding to the promoter of miR-130b (a negative regulator of ZEB1) and inhibiting its transcription. 22847613

2013

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 Biomarker CTD_human Although high expression of ZEB1 mRNA is estrogen-dependent in normal human ovarian and endometrial biopsies, high expression is estrogen-independent in late stage ovarian and endometrial carcinomas, raising the possibility that deregulated expression promotes cancer progression. 18622689

2008

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE In addition, as we previously reported, ZEB1 is aberrantly expressed in the epithelial-derived tumor cells of highly aggressive endometrial cancers, such as FIGO grade 3 endometrioid adenocarcinomas, uterine serous carcinomas, and malignant mixed Müllerian tumors (classified as type II endometrial cancers). 18487993

2008

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE Although high expression of ZEB1 mRNA is estrogen-dependent in normal human ovarian and endometrial biopsies, high expression is estrogen-independent in late stage ovarian and endometrial carcinomas, raising the possibility that deregulated expression promotes cancer progression. 18622689

2008

Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.380 AlteredExpression BEFREE In malignancies of the uterus, we find that ZEB1 (a) is overexpressed in malignant tumors derived from the myometrium (leiomyosarcomas), (b) is overexpressed in tumor-associated stroma of low-grade endometrioid adenocarcinomas, and (c) is aberrantly expressed in the tumor epithelial cells of aggressive endometrial cancers. 16585218

2006