Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.160 GeneticVariation GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016

2018

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.160 Biomarker BEFREE We hypothesize that genetic variants in the Wnt pathway effector, Transcription factor 7-like 2 (TCF7L2), may influence clinical outcomes in prostate cancer. 25678841

2015

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.160 GeneticVariation BEFREE We observed a non-significant tendency for the TCF7L2 variant to associate with higher risk of PCa, which was unaffected by adjustment for incident T2D (HR = 1.24; 95% CI: 0.96, 1.60; P = 0.079) but more pronounced among subjects who developed T2D (HR = 1.91, 95% CI: 0.88, 4.14; P = 0.064). 24961829

2014

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.160 GeneticVariation BEFREE The results showed that TCF7L2 polymorphism was associated with breast cancer (Homogeneous model: OR=1.17, 95%CI=1.02-1.35, I (2) =21.8%, p for heterogeneity=0.276; Heterogeneous model: OR=1.11, 95%CI=1.03-1.20, I (2) =0.0%, p for heterogeneity=0.543), prostate cancer (Homogeneous model: OR=0.89, 95%CI=0.84-0.96, I (2) =0.0%, p for heterogeneity=0.640; Heterogeneous model: OR=0.89, 95%CI=0.84-0.95, I (2) =0.0%, p for heterogeneity=0.871), and colon cancer (Heterogeneous model: OR=1.15, 95%CI=1.01-1.31, I (2) =0.0%, p for heterogeneity=0.658), but not with colorectal cancer, lung cancer, and ovarian cancer. 23951231

2013

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.160 GeneticVariation BEFREE The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR, 0.79; 95% CI, 0.65-0.97). 20142250

2010

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.160 GeneticVariation BEFREE These results need to be confirmed, but provide initial evidence that the TCF7L2 gene may alter risk of developing more aggressive prostate cancer. 18302196

2008

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.160 Biomarker BEFREE Androgen receptor (AR) interacts with beta-catenin and can suppress its coactivation of T cell factor 4 (Tcf4) in prostate cancer (PCa) cells. 16428447

2006