Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE The dominant Th cytokines across all breast cancer samples were IFN-γ and IL-2. 31428522

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Breast cancer lines were broadly sensitive to the combination of IFN-γ and TNF-α, as evidenced by lower metabolic activity, lower proliferation, and enhanced apoptosis, and in some cases a reversible inhibition of surface expression of HER proteins. 31666931

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE With a view toward improving complete response rates, we investigated whether the principle Th1 cytokines (IFN-γ and TNF-α) could act in concert with lapatinib to suppress activity of breast cancer lines in vitro. 30657766

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Our findings suggest that long-term application of IFN-γ may be closely associated with the promotion of cell growth and even the carcinogenesis of breast cancer. 30614229

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-γ (nutritionally induced) both in vitro and in vivo, and IFN-γ was higher in breast cancer women. 29746817

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer. 30336781

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Furthermore, cell from normal mammary epithelium and breast cancer cell lines expressed ICAM1 upon stimulation with the proinflammatory cytokines TNFα, IL1β and IFNγ. 30082828

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Certain well-known oncogenes (MYC and HGF), cytokines (CSF2, IFNG and IL5) and microRNAs (miR-21, miR-155-5p and let-7) may participate in the ILF2 expression network in breast cancer. 30018709

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Membrane-bound FasL expression could be induced by IFNγ in a breast cancer cell model. 29185091

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Association of breast carcinoma growth with a non-canonical axis of IFNγ/IDO1/TSP1. 29156701

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE These findings identify IRF8 as a novel tumor suppressor regulating IFN-γ/STAT1 signaling and β-catenin signaling in breast cancer. 28388578

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE The prognostic time dependence of intra-tumoural IFNγ mRNA and protein in patients with breast cancer followed for 14 years after surgery and radiotherapy, without subsequent systemic therapy. 29478965

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Targeting IL4 signaling sensitized breast cancer cells to anticancer therapy and strengthened immune responses by enhancing the number of IFNγ-positive CTLs. 28400477

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE In this study, we discovered that the B cells in breast cancer patients were enriched with interferon (IFN)-γ-expressing cells and presented high potency for IFN-γ production. 29054490

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE In vitro, compared with mock-transduced NK-92 cells or primary NK cells, EGFR-CAR-engineered NK-92 cells and primary NK cells displayed enhanced cytotoxicity and IFN-γ production when co-cultured with breast cancer cell lines MDA-MB-231, MDA-MB-468, and MCF-7. oHSV-1 alone was also capable of lysing and destroying these cells. 27050072

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE ADAM17-expressing human breast cancer cell lines MCF-7 and MDA-MB-453 also degraded recombinant IFN-γ, but this was attenuated by ADAM17 inhibition. 27573075

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE These results indicate that ERβ and autocrine IFN-γ represent two putative targets for breast cancer therapy. 26397740

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer. 26563945

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 GeneticVariation BEFREE To that effect, polymorphisms in genes coding for IL-4 (IL-4 C-590T; rs2243250), IFN-γ (IFN-G A + 874T; rs2430561) and MCP-1 (MCP-1 A-2578G; rs1024611) were examined in premenopausal, healthy women (N = 239) and patients with breast cancer (N = 182) from western India. 24164868

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 GeneticVariation BEFREE Subgroup analysis based on ethnicity suggested that genetic polymorphisms in the IFN-γ gene were closely correlated with increased breast cancer risk among Asians (allele model: OR = 1.21, 95 % CI = 1.02 ~ 1.58, P = 0.017; dominant model: OR = 3.44, 95 % CI = 2.07 ~ 5.71, P < 0.001; recessive model: OR = 1.58, 95 % CI = 1.06 ~ 2.37, P = 0.025; homozygous model: OR = 1.83, 95 % CI = 1.19 ~ 2.80, P = 0.006; respectively), but not among Caucasians (all P > 0.05). 25051917

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Basal type breast cancer (especially basal B) express greater levels of PD-L1 constitutively and with IFN γ. 24551119

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE ROC curve analyses demonstrated that only IFN-γ has the ability to distinguish either presence of breast cancer or breast cancer in localized or metastatic form, whereas IL-18 and NO can detect only metastasis. 25335731

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE HLA-II in breast carcinoma is associated with increased IFN-γ levels, reduced expression of the estrogen receptor (ER) and reduced age at diagnosis. 24475282

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE CXCL12, CXCR4 and IFNγ genes expression: implications for proinflammatory microenvironment of breast cancer. 22699677

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In addition, Ad-MGBA-infected DC-stimulated CD8(+) CTLs showed a high level of IFNγ secretion when stimulated with HLA-A33(+)/MGBA(+) breast cancer MDA-MB-415 cells, but not when stimulated with HLA-A33(-)/MGBA(+) HBL-100 and HLA-A33(-)/MGBA(-)MDA-MB-231 cells. 23650543

2013