Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2074
Gene Symbol: ERCC6
ERCC6
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.430 GeneticVariation BEFREE However, the combined variant genotypes of the four loci with P(trend) approaching to 0.10 (rs2228526, rs4253160, rs12571445 and rs3793784) were associated with a significantly increased lung cancer risk (adjusted OR 1.35, 95% CI, 1.04-1.75 among subjects carrying three or more variant alleles), indicating that multiple loci in ERCC6 may jointly contribute to the susceptibility of lung cancer. 18789574

2009
Entrez Id: 2074
Gene Symbol: ERCC6
ERCC6
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.430 GeneticVariation BEFREE Our data constituted strong evidence that ERCC6 rs3793784:C>G alters its transcriptional activity and may confer personalized susceptibility to lung cancer. 17854076

2008
Entrez Id: 2074
Gene Symbol: ERCC6
ERCC6
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.430 Biomarker BEFREE Our results suggest that individuals whose expression levels of XPG/ERCC5 and CSB/ERCC6 are reduced may be at higher risk of lung cancer. 10910954

2000
Entrez Id: 2074
Gene Symbol: ERCC6
ERCC6
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.430 Biomarker GENOMICS_ENGLAND

Entrez Id: 2074
Gene Symbol: ERCC6
ERCC6
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.430 CausalMutation CLINVAR