Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells. 31711466

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer. 30224342

2019

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 Biomarker BEFREE BRAF Mutant Lung Cancer: Programmed Death Ligand 1 Expression, Tumor Mutational Burden, Microsatellite Instability Status, and Response to Immune Check-Point Inhibitors. 29723688

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 Biomarker BEFREE A group of thoracic oncology experts in the field of thoracic oncology met to describe the standard for biomarker testing for lung cancer in the Canadian context, focusing on evidence-based recommendations for standard-of-care testing for <i>EGFR</i>, anaplastic lymphoma kinase (<i>ALK</i>), <i>ROS1</i>, <i>BRAF V600</i> and programmed death-ligand (PD-L1) at the time of diagnosis of advanced disease and <i>EGFR T790M</i> upon progression. 29507487

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 Biomarker BEFREE The novel BRAF Thr599dup gene mutation, for which the repeat amino acid-tyrosine is inserted between the 599th amino acid and the 600th amino acid in exon 15 of BRAF, was identified by next-generation sequencing (NGS) during routine clinical care in a lung carcinoma sample from an Asian never-smoker. 30019008

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE These results indicate that AZ628 has greater potential than Dabrafenib, both as a single agent and combined with Trametinib, for the treatment of non-V600 BRAF mutant lung cancer. 29662630

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Economic analysis of BRAF gene mutation testing in real world practice using claims data: costs of single gene versus panel tests in patients with lung cancer. 29516752

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Accordingly, the combination of MEK inhibitor with EGFR inhibitor was effective at shrinking tumors in mouse model of BRAF non-V600E mutant lung cancer. 29348459

2018

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Therapeutic approach to treating patients with BRAF-mutant lung cancer: latest evidence and clinical implications. 28203297

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC). 28625649

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib. 28947956

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations? 28012356

2017

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D)-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S)-mutation. 27863474

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 Biomarker BEFREE One of our predicted biomarker pairs, a mutation in the BRAF gene and upregulated expression of the PIM1 gene, was experimentally validated to benefit from a therapy combining BRAF inhibitor and PIM1 inhibitor in lung cancer. 26916442

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE ATM loss also enhances the sensitivity of KRAS- or BRAF-mutant lung cancer cells to MEK inhibition. 27922010

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. 27834212

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Our clinical data suggest that BRAF mutations define specific subsets of patients with NSCLC; while their oncogenic nature is yet to be established in lung cancer, especially for non-V600E mutations, the value of BRAF mutations to predict the efficacy of targeted agents remains unclear. 26711930

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 AlteredExpression BEFREE Recent evidence shows that BRAF-activated non-coding RNA (BANCR) acts as a critical role in the proliferation and metastasis in malignant melanoma and lung cancer; however, little is known about the significance of lncRNA BANCR in retinoblastoma. 25894373

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE We developed a highly sensitive LUNG CANCER (LC)-biochip approach for the detection of the most common EGFR, KRAS, PIK3CA, and BRAF gene mutations. 25153497

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE We conducted a retrospective multicenter cohort study in Europe of patients with advanced BRAF-mutant lung cancer treated with known BRAF inhibitors. 26200454

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 Biomarker BEFREE Jointly, our results suggest a potential role of the novel BRAF fusion in lung cancer development and therapy. 25985019

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) mutated lung cancer is relatively aggressive and is resistant to currently available therapies. 25706985

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Combined genomic and proteomic analyses demonstrated infrequent alteration of validated lung cancer targets (including the absence of BRAF mutations in TTF1-negative LUAD), but identified novel potential targets for TTF1-negative LUAD, including KEAP1/Nrf2 and DNA repair pathways. 25878335

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 GeneticVariation BEFREE Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium. 25273224

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.700 Biomarker BEFREE Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer. 24550319

2014