Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE Furthermore, CENPO knockdown decreased ataxia telangiectasia mutated (ATM), cyclin D1 and c‑Jun expression, indicating that the ATM signaling pathway may be involved in CENPO‑mediated regulation of GC cell growth. 31485675

2019

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma. 31206368

2019

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE PD-L1 membrane expression on tumour cells (TC) and infiltrating immune cells (IC), CD3 + T-lymphocytes, CD8+ cytotoxic T-cells, ATM and HER2 were assessed by immunohistochemistry (IHC) in the ACRG (Asian Cancer Research Group) GC cohort (N = 380). 30729066

2019

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE The clinical significance of PD-L1 in advanced gastric cancer is dependent on <i>ARID1A</i> mutations and ATM expression. 30221053

2018

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE HOXC10 promoted GC cell invasion and migration, regulated the expression of activated ATM and markers of NF-κB signaling. 29753747

2018

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Further clinical studies on the interaction between AZD 6738 and ATM deficiency are warranted to develop novel treatment strategies for gastric cancer.<i></i>. 28138034

2017

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE ATM was downregulated in GC patients in Xinjiang, especially for Uygurs and Kazaks, which suggested ATM to be an independent indicator of prognosis for GC therapy. 28647209

2017

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Although ATM was shown to be associated with poor prognosis in gastric cancer, its implications as a predictive biomarker for cancer chemotherapy remain unexplored. 27638859

2016

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE In addition, data revealed hsa-let-7 g miRNA increased the sensitivity of GC to X-rays involving in ATM regulation as well according to application of X-rays (another DDR inducer). 25972194

2015

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Loss-of-function variants in ATM confer risk of gastric cancer. 26098866

2015

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis. 26587992

2015

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Further evaluation of ATM mutations in hereditary gastric cancer will facilitate genetic testing and risk assessment. 26506520

2015

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. 24841718

2014

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues. 24531888

2014

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 AlteredExpression BEFREE Ataxia-telangiectasia-mutated protein expression with microsatellite instability in gastric cancer as prognostic marker. 23649938

2014

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Expression loss of breast cancer type 1 susceptibility protein (BRCA1), ataxia telangiectasia mutated (ATM), ATM-Rad3-related (ATR), mediator of DNA damage checkpoint protein 1 (MDC1) and meiotic recombination 11 (Mre11) were correlated with their clinicopathological parameters in gastric cancer (GC). 23569343

2013

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Cytotoxicity of 5-Aza-2'-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of P16(INK4A). 23201008

2013

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE Two human GC cell lines (SNU-1 and -638) showed ATM intron mutations, deletion in RT-PCR and direct sequencing, and ATM protein loss by IHC. 24324828

2013

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 Biomarker BEFREE Our findings suggest that ATM mutations might be a pathogenic factor for an increased risk of gastric cancer, and the dysfunction of ATM may lead to a hypersensitivity to ionizing radiation in gastric cancer cells, possibly by a p53-dependent pathway. 14706517

2004

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GeneticVariation BEFREE No evidence for constitutional ATM mutation in breast/gastric cancer families. 9592204

1998

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 CausalMutation CGI

Entrez Id: 472
Gene Symbol: ATM
ATM
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.400 GenomicAlterations CGI