Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment. 31376137

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE The receptors for HER2 are overexpressed in various human cancers, such as breast and ovarian cancer. 31470531

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE The aim of the multicenter study is to investigate the correlation between the expression of estrogen alpha receptors (ERα), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), stromal cell-derived factor 1 (SDF1) and its receptor C-X-C chemokine receptor type 4 (CXCR4), breast cancer metastasis suppressor 1 (BRMS1), astrocyte elevated gene 1 (AEG1), depending on the status of BRCA1 protein, in patients suffering from OC and BC with brain metastases. 30822630

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE Overexpression of HER2/HER3 and clinical feature of ovarian cancer. 31328457

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE HER2 amplifications and overexpression in ovarian cancer are reported to vary, and responses to HER2 inhibitors have been poor. 30499260

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE However, analyses that considered all 41 genes with clinical variables together identified genes TLR4, BSCL2, CDH1, ERBB2, BRCA2 and SCGB2A1 as independently related to survival in OC. 31655274

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE In conclusion, HER2 protein is over-expressed in epithelial ovarian cancer tissues, and trastuzumab exerts anti-tumor effect by inhibiting cell proliferation and inducing apoptosis, suggesting it might be a novel approach for the treatment of ovarian cancer. 30509111

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE In order to assess the validity of ErbB2-targeted therapy in ovarian cancer, we investigated the effectiveness of two FDA-approved tyrosine kinase inhibitors of ErbB2, lapatinib and neratinib, on the growth of ovarian cancers. 31689531

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Cisplatin-loaded PLGA nanoparticles for HER2 targeted ovarian cancer therapy. 30856589

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE We used six whole-exome-sequenced primary HGSOC/USC cell-lines and three xenografts overexpressing HER2/neu and harboring mutated or wild-type PIK3CA/PIK3R1 genes to evaluate the role of PI3K-mutations as potential mechanism of resistance to afatinib, an FDA-approved pan-c-erb-inhibitor in clinical trials in USC. 30630630

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE Aberrant <i>EGFR</i> expression and <i>ERBB2/3/4</i> mRNA levels were associated with OC prognosis. 30588099

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE HER2-targeting properties and biodistribution were evaluated in BALB/C <i>nu/nu</i> mice bearing ovarian carcinoma cell (SKOV-3) xenografts. 28864631

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE The prognostic role of human epidermal growth factor receptor 2 (HER2) in ovarian cancer has been investigated in previous studies, but the results remain controversial. 29381731

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Genetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis. 29535531

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE HER2 is a member of epidermal factor receptor (EGFR) family which is overexpressed in breast cancer, ovarian cancer and gastric cancer. 30225583

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE The data demonstrate that the growth of xenografts of human ovarian cancer with high expression of HER2 could be inhibited effectively by Ad-HER2-siRNA+DDP. 30052070

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Neratinib inhibits xenograft growth and improves overall survival in HER2/neu-amplified ovarian cancer in vivo.Clinical trials are warranted. 28397106

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE PET imaging and biodistribution studies in subcutaneous models of ovarian cancer were performed for non-invasive in vivo evaluation of HER2 expression. 28265738

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE Our study showed that the expressions of HER2, STAT3, and SOCS3 are associated with the progression of OC, and higher expressions of HER2 and STAT3 and lower expression of SOCS3 predict poor prognosis of OC. 28448787

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE HER2 is overexpressed in 20-25% of breast and ovarian cancers. 27693491

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Association of HER2 codon 655 polymorphism with ovarian cancer. 26666819

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Our results demonstrated that Gigantoxin-4-4D5 scFv exerted a highly cytotoxic effect on the HER2/neu-positive ovarian carcinoma SK-OV-3 cell line. 27063011

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE A novel far-red fluorescent xenograft model of ovarian carcinoma for preclinical evaluation of HER2-targeted immunotoxins. 26436696

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 AlteredExpression BEFREE The aim of this study was to investigate the potential prognostic value of SKP2, genes P27Kip1, K-ras, c-Myc, COX2 and HER2 genes expression in ovarian cancer. 26320455

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Together, these data indicate that HER2 represents an important oncogene in ovarian cancer, and suggest that targeting this tyrosine kinase with T-DM1 may be therapeutically effective, especially in ovarian tumors with high content of HER2. 26336133

2015