Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation BEFREE TP53 mutations were associated with extramural venous invasion on baseline MRI (78% vs. 65%, p = 0.04), poor pathological tumour regression (23% vs. 36%, p = 0.05) and a trend toward a worse 5-year progression-free survival (PFS; 60% vs. 74%, HR 1.59, p = 0.06). 31199501

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE The circ_0021977/miR-10b-5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer. 31595500

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Long non-coding RNA GAS5 inhibits migration and invasion in gastric cancer via interacting with p53 protein. 31530437

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation BEFREE Paradoxically, mutant p53 represses genes associated with increased cell viability, migration, and invasion. 31067569

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE We demonstrated that CCDC106 knockdown enhanced apoptosis by stabilizing p53 and suppressed cell viability, colony formation, migration and invasion in cervical cancer HeLa and breast cancer MCF7 cells with wild-type p53 (wtp53), whereas CCDC106 overexpression exerted the opposite effects in normal breast epithelial HBL100 and cervical cancer SiHa cells with wtp53. 30885251

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation BEFREE A gain of function (GOF) of p53 mutants promotes cell proliferation, migration and invasion through multiple mechanisms. 31795192

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE In human non-small cell lung cancer cell line, H1299 cells transfected with various p53 lentivirus vectors, mut-p53 could promote the invasion and motility of cells under IR, mainly through the EMT. 30732622

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. 31835405

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation BEFREE Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis, and gene expression in mouse colon tumorigenesis. 31148594

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation BEFREE Mouse model studies have shown that one of these missense-type mutations, p53 R270H (corresponding to human R273H), causes submucosal invasion of intestinal tumors, while the loss of wild-type p53 has a limited effect on the invasion process. 30496442

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE We aimed to assess the prognostic roles of the Ki-67 proliferation index, mitotic index, P53 expression, and cavernous sinus invasion in pituitary adenomas (PAs). 30610566

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Recent studies show that p53 activation in the myeloid linage suppresses alternative (M2) macrophage polarization, and attenuates tumor development and invasion, leading to the hypothesis that p53 activation may augment antitumor immunity elicited by anti-PD-1 therapy. 31779710

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Our data indicated that blocking p53 expression and mediated signal pathways contribute to the positive effects of miR-151a-3p on NPC cell proliferation, migration and invasion. 31652456

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Notably, the sum of the immunohistochemical expression of p53 was significantly correlated with patient age (P=0.037), histologic type (P=0.008), histologic grade (P=0.002) and fallopian and/or ovarian invasion (P=0.014). 30944646

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE ΔNp63α, a member of the p53 family of transcription factors, is overexpressed in a number of cancers and plays a role in proliferation, differentiation, migration, and invasion. 31515469

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Our study suggests that LKB1 expression is reduced in GC, negatively correlated with p53 and survivin expression, and plays an important role in predicting invasion and metastasis of GC. 30863111

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Moreover, a series of LDHA gain-of-function and rescore experiments were carried out in breast cancer MCF7 cells expressing endogenous wt-p53, showing that ectopic expression of p53 decreases aerobic glycolysis, cell proliferation, migration, invasion and tumor formation of breast cancer cells and that restoration of the expression of LDHA in p53-overexpressing cells could abolish the suppressive effect of p53 on aerobic glycolysis and other malignant phenotypes. 30618169

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Cancer cells acquire selective advantages by retaining mutant forms of the protein, which radically subvert the nature of the p53 pathway by promoting invasion, metastasis and chemoresistance. 30538286

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE What is more, the inhibitory effect of Inotodiol on tumor migration and invasion was blocked under p53 knockdown. 31128995

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE The protein expression levels of p53 were highest in cancer tissues, but the levels revealed no correlation with the presence of the HBV antigen, the tumor diameter, the AFP levels, the pathologic grade, or the invasion and metastasis capabilities of the tumor tissues (p>0.05). 28952211

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Knockdown of PPP2R3A resulted in significant inhibition of hepatoma cell proliferation (P < .05), migration (P < .01), and invasion (P < .01) as well as a significant delay in the G1/S transition in both liver cancer lines (P < .05) and increased p53 expression. 31647192

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 PosttranslationalModification BEFREE Cell viability and proliferation, cell cycle analysis, cell migration and invasion and protein expression and phosphorylation status of Akt and p53 upon SFN treatment were determined. 28864908

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE The selected miR-122 effectively inhibited the expression of TP53 gene in Hela cells, and enhanced their proliferation, migration, and invasion. 29687846

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE This transcriptional rewiring renders p53 a significant contributor to the distinct intrinsic features of CAFs, as well as promotes tumor cell migration and invasion in culture. 29866855

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. 30107178

2018