Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Sohlh2 alleviates malignancy of EOC cells under hypoxia via inhibiting the HIF1α/CA9 signaling pathway. 31318683

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Hence, targeting HIF-1 pathway is regarded as a promising strategy to treat cancer. 31724069

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Our research indicates that the UCHL1-HIF-1 pathway plays a crucial role in tumor malignancy, making it a promising therapeutic target for cancer chemotherapy. 31729096

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Hypoxia-inducible factor-1α (HIF-1α) induces cancer metastasis. 31813546

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role in apoptosis, metastasis, and proliferation and is recognized as an important potential therapeutic target for cancer. 31810777

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia. 31784651

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Inhibiting the HIF-1α-p300 interaction modulated the HIF-1α identification of selective molecules, which may indicate the target metabolic and cellular processes that enable the survival and growth of tumors in cancer chemotherapy. 30784357

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Superoxide generation rate, activity of complex I in electron transport chain of mitochondria, activity of matrix metalloproteinase (MMP-2 and 9) of adipose tissues (AT) of patients with gastric cancer in AT located adjacent to tumor (ATAT) and at a distance of 3 cm (ATD) are measured to follow the connection of the redox state with some of the microenvironment indicators (HIF-1α, CD68, Plin5), body mass index (BMI) and cancer metastasis. 31711773

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Small molecules targeting HIF-1α pathway for cancer therapy in recent years. 31843464

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE HIF-1 is regarded as a promising target for the drugs used in cancer chemotherapy, and creating readily accessible templates for the development of synthetic drug candidates that could inhibit HIF-1 transcriptional activity is an important pursuit. 31740202

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Previous studies had indicated that normoxic activation of HIF-1α in cancer involves inhibition or mutation of the metabolic enzyme succinate dehydrogenase (SDH). 31259781

2020

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Immunohistochemical expression of HDAC6, hypoxia inducible factors-1α (HIF-1α), programmed death-1 ligand (PD-L1), CD44 (cancer stem cell marker), and ARID1A was analysed for 106 OCCC patients. 30787326

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis. 31744467

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE After an appropriate number of cancer tissues were taken, the experimental group was treated with oral administration of 500 mg vitamin B3 every day, while the placebo group was treated with oral administration of the same amount of placebo; after 1 week, the skin cancer tissues in the same part were taken, and the skin tissues of healthy people were taken as the control group; the mRNA and protein expression levels of HIF-1α and p53 in tissues were detected. 29064206

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE In this review, we summarize the recent information on HIF-1α in gastric cancer with special focus on the mechanism underlying HIF-1α signaling effects on proliferation, apoptosis, angiogenesis, EMT and drug-resistance of cancer cells, thereby predicting new therapeutic agents for better management of this malignancy. 30782242

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Among iron-dependent dioxygenases, important targets for stimulation by vitamin C in cancer include prolyl hydroxylases targeting the hypoxia-inducible factors HIF-1/HIF-2 and histone and DNA demethylases. 30695991

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. 31531455

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Ascorbate can moderate HIF-1 activity in vitro and is associated with HIF pathway activation in a number of cancer types, but whether tissue ascorbate levels influence the HIF pathway in breast cancer is unknown. 30943919

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Therefore, HIF-1 is a viable target for cancer therapy. 31485300

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE In this review, recent progress of small molecular inhibitors of protein-protein interactions targeting HIF-1 is summarized, the mechanism of functions of these compounds and their potential usage as anti-cancer agents have also been discussed. 30819620

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE The angiogenic markers, miR-210 and HIF-1α, do not appear to distinguish malignancy in salivary glands. 30902790

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival. 30538116

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE This pathway may reprogram mitochondrial dynamics to differentially adjust energy production or promote tumor cell invasion in response to microenvironment conditions.-Wang, Y., Agarwal, E., Bertolini, I., Ghosh, J. C., Seo, J. H., Altieri, D. C. IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state. 31530011

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Taken together, these results suggest that TNC may enhance the cancer stem-like properties and promote EMT-like changes via the Akt/HIF1α axis. 30904401

2019

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Taken together, our data suggest that KDELR2 is a target gene downstream of HIF1-alpha driving the malignancy of GBM and could eventually serve as a therapeutic target for the treatment of GBM patients. 31342232

2019