Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation BEFREE Compared with non-carriers, PALB2 pathogenic mutation carriers developed breast cancer at a younger age (47.52 years vs. 51.35 years, p = 0.016) and were more likely to have triple-negative (24.1% vs. 13.4%, p = 0.022) or HER2 negative (87.0% vs. 74.2%, p = 0.031) breast cancer and large breast tumors (> 2 cm) at diagnosis (72.2% vs. 57.0%, p = 0.024). 31768816

2020

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation BEFREE RAD51 foci formation and PALB2 LOH status were evaluated in primary breast tumor samples from the carriers. 30552643

2019

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. 28825726

2017

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation BEFREE Where possible, relatives of women found to carry PALB2 mutations were genotyped for the family-specific mutation, mutant transcripts were characterised and breast tumours arising in mutation carriers were recalled and reviewed. 23448497

2013

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker BEFREE Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. 23657012

2013

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation BEFREE Systematic pathology review was conducted on breast tumours from 28 female carriers of PALB2 mutations (non-carriers of other known high-risk mutations, recruited through various resources with varying ascertainment) and on breast tumours from a population-based sample of 828 Australian women diagnosed before the age of 60 years (which included 40 BRCA1 and 18 BRCA2 mutation carriers). 23787919

2013

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 AlteredExpression LHGDN Aberrant promoter hypermethylation of PALB2 is more frequent than the reported level of PALB2 point mutations in breast tumors from BRCA1/2-negative families and is similar to the frequency of BRCA1 hypermethylation in inherited and sporadic breast and ovarian cancers. 18281473

2008

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 PosttranslationalModification BEFREE Aberrant promoter hypermethylation of PALB2 is more frequent than the reported level of PALB2 point mutations in breast tumors from BRCA1/2-negative families and is similar to the frequency of BRCA1 hypermethylation in inherited and sporadic breast and ovarian cancers. 18281473

2008

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker LHGDN Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories? 18557994

2008

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN Penetrance analysis of the PALB2 c.1592delT founder mutation. 18628482

2008

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN Association of common PALB2 polymorphisms with breast cancer risk: a case-control study. 18794107

2008

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN A recurrent mutation in PALB2 in Finnish cancer families. 17287723

2007

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. 17200668

2007

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN Analysis of PALB2/FANCN-associated breast cancer families. 17420451

2007

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 GeneticVariation LHGDN Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women. 18053174

2007

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker LHGDN Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. 16793542

2006

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 CausalMutation CLINVAR