Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE The interferon-gamma (IFN-γ) releasing assay (IGRA) is widely used for latent tuberculosis infection (LTBI) diagnosis. 31432637

2020

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Five enrollment strategies were assessed: 1) Enroll based on no LTBI diagnostic test, 2) Enroll based on a positive tuberculin skin test (TST), 3) Enroll based on a positive interferon gamma release assay (IGRA), 4) Enroll based on either a positive TST or IGRA, 5) Enroll regardless of test result, assuming 70% had negative TSTs, 20% positive TSTs, and 10% unknown results. 31711306

2020

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Of these, 37 (32%) presented LTBI - tuberculin skin test was positive in 18 (49%) patients; interferon gamma release test was positive in 14 (38%) patients and undetermined in seven (19%); and there was a history of exposure in 12 (32%) patients. 31206406

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE The laboratory diagnosis of latent tuberculosis infection (LTBI) is mainly performed with interferon gamma release assays (IGRAs). 31533984

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Interferon gamma release assay (IGRA) was used for the diagnosis of LTBI. 31561559

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE <i>Mycobacterium tuberculosis</i>-Induced Bronchoalveolar Lavage Gene Expression Signature in Latent Tuberculosis Infection Is Dominated by Pleiotropic Effects of CD4<sup>+</sup> T Cell-Dependent IFN-γ Production despite the Presence of Polyfunctional T Cells within the Airways. 31541022

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 GeneticVariation BEFREE We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). 29764958

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 GeneticVariation BEFREE Estimating the annual risk of tuberculosis infection in Japan from interferon-gamma release assay data. 30315813

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Good Agreement between an Interferon Gamma Release Assay and Tuberculin Skin Tests in Testing for Latent Tuberculosis Infection among HIV-Infected Patients in Indonesia. 31625291

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE The overall initiation rate of LTBI treatment was suboptimal in HCWs with LTBI diagnosed using an interferon-gamma releasing assay. 30635600

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Interferon-gamma release assays (IGRAs) are blood tests used to measure the amount of interferon-γ (IFN-γ) released by T lymphocytes after stimulation by antigens specific for the diagnosis of latent tuberculosis infection. 31132974

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Current guidelines recommend screening for latent tuberculosis infection (LTBI) with a tuberculin skin test (TST) or interferon gamma release assay (IGRA), or both. 31363778

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE The use of interferon gamma release assays for detection of latent tuberculosis is discussed and compared to tuberculin skin testing. 30817030

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE The tuberculin skin test (TST) and interferon-gamma-release-assays (IGRAs) are utilized in screening programmes for presumed latent tuberculosis infection (LTBI) in health care workers (HCWs). 30736743

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Diagnosis of LTBI relies on presence of immune-reactivity to TB antigen and commonly used tests include tuberculin skin test and interferon gamma release assay (IGRA). 30741387

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Current tests measure an immunologic response and include the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs), T-SPOT.TB and QuantiFERON. 31731987

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Given the lack of a gold standard for latent tuberculosis infection (LTBI) and paucity of performance data from endemic settings, we compared test performance of the tuberculin skin test (TST) and two interferon-gamma-release assays (IGRAs) among health-care workers (HCWs) using latent class analysis. 31416206

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE A strategy is described for continuous monitoring of multiple latent tuberculosis infection (LTBI) biomarkers, specifically of interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-2 (IL-2). 30830301

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE When compared to gold standard technology (interferon gamma release assay or IGRA), our encapsulated immunoassay accurately predicted LTBI diagnosis in 11 out of 14 patients. 30776214

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Superiority of Interferon Gamma Assay Over Tuberculin Skin Test for Latent Tuberculosis in Inflammatory Bowel Disease Patients in Brazil. 30673986

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Diagnostic accuracy of interferon-gamma-induced protein 10 for differentiating active tuberculosis from latent tuberculosis: A meta-analysis. 31388072

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 GeneticVariation BEFREE In the present study, we found that <i>IFNG</i> and <i>IFNGR1</i> polymorphisms were associated with LTBI. 31687049

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Incidence and risk factors of latent tuberculosis tests conversion (interferon gamma release assays [IGRA], tuberculin skin tests [TST], and chest radiography [CXR]) with clinical outcomes were studied. 29757355

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE Comparison of tuberculin skin test and interferon gamma release assay for diagnosis of latent tuberculosis infection in pediatric candidates of renal transplantation. 29388291

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis
0.100 Biomarker BEFREE At our institution, CXR was performed for all patients undergoing a tuberculin skin test (TST) and/or an interferon-gamma release assay (IGRA) at the LTBI screening visit. 30261981

2018