Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE The in vitro cell growth inhibitory activity of compounds <b>5</b>, <b>6</b>, <b>7</b>, <b>9</b>, and <b>10</b> was investigated in six human tumor cell lines: A375-C5 (malignant melanoma IL-1 insensitive), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), U251 (glioblastoma astrocytoma), U373 (glioblastoma astrocytoma), and U87MG (glioblastoma astrocytoma). 29734739

2018

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE CD133 Regulates IL-1β Signaling and Neutrophil Recruitment in Glioblastoma. 28736425

2017

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Glioblastoma microenvironment contains high levels of TNFα and IL-1β, which mediate inflammation through induction of a local network of cytokines and chemokines. 26794430

2016

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Furthermore, elevated IL-1β levels in GBM tumours are also believed to activate GBM cells and enhance IL-6 production. 25088200

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE The Proneural subgroup of the TCGA GBM patient dataset with high IL1β expression showed shorter survival compared to patients with low IL1β. 25987130

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Biphasic effects of luteolin on interleukin-1β-induced cyclooxygenase-2 expression in glioblastoma cells. 25409926

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE Our findings suggest that when estimating the influence of IL-1β on the prognosis of glioblastoma patients, factors such as the degree of hypoxia, the expression levels of HIF-1 and AM should be taken into consideration. 24457964

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE Specifically, the ability to produce IL-1 by glioblastoma cells may confer them a mesenchymal phenotype including increased migratory capacity, unique gene signature and proinflammatory signaling. 25054228

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE The secretion of IL-1β from glioblastoma cells in turn stimulates the expression of COX-2 in human or mouse neuroblastoma cells. 24621265

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE We have previously shown that IL-1β-HIF-1α axis connects inflammatory and oncogenic pathways in GBM. 23220408

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma. 20865400

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE In summary, our results suggest that SphK1 expression is transcriptionally regulated by IL-1 in glioblastoma cells, and this pathway may be important in regulating survival and invasiveness of glioblastoma cells. 19074142

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Collectively, these results indicate that S1P and IL-1 activate distinct pathways leading to the mRNA and protein expression of PAI-1 and uPAR, which are important for glioblastoma invasiveness. 18819934

2008

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker CTD_human A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines. 16356833

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE Since malignant gliomas frequently show EGF receptor amplification and express IL-1, a pivotal regulatory cytokine involved in angiogenesis, we analyzed interactions between EGF/EGF receptor and IL-1/IL-1 receptor and VEGF in the established glioblastoma cell lines U-87 MG and A-172. 10571418

1999

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Northern blot analysis showed that treatment with interferon-gamma and with interleukin-1beta for 24 h decreased the expression levels of heme oxygenase-1 mRNA to approximately 20 and approximately 50% of the control levels, respectively, in a human glioblastoma cell line, T98G. 10349844

1999

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Using RT-PCR, Northern blotting, and ELISA we demonstrated that the human U373 and U87 glioblastoma cell lines expressed IL-11 and its encoding mRNA when stimulated with IL-1 beta, phorbol ester, and calcium ionophore. 7501271

1995

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1). 8175759

1994

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 Biomarker BEFREE Finally, immunohistological analysis on fresh frozen tumour sections provided evidence for IL-1 production by glioblastoma cells in vivo. 8512018

1993

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.400 AlteredExpression BEFREE Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha. 1937574

1991