Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Lgr5-mediated p53 Repression through PDCD5 leads to doxorubicin resistance in Hepatocellular Carcinoma. 31244936

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE This underscores the need for combinatorial approaches with focus on PXR antagonism to improve drug effectiveness in hepatocellular carcinoma.<b>Abbreviations:</b> HCC: Hepatocellular Carcinoma; FDA: Food and Drug Administration; TGF-β: Transforming growth factor-β; PXR: Pregnane X receptor; CAR: Constitutive androstane receptor; P-gp/ABCB1: P-glycoproteins/ATP-binding cassette transporter subfamily B member 1; MRP1/ABCC1 and MRP2/ABCC2: Multidrug-resistance associated proteins; BCRP/ABCG2: Breast cancer resistant protein; DMEs: Drug-metabolizing enzymes; CFDA: 5,6-carboxyfluorescein diacetate; ETS1: Transcription factor E26 transformation specific sequence 1. 31739702

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 GeneticVariation BEFREE MDR1 gene polymorphism correlated with pathological characteristics and prognosis in patients with primary hepatocellular carcinoma receiving interventional therapy. 30779721

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE These results indicate that elevated ABCB1 expression induced by C-terminal truncation of HBx was responsible for doxorubicin resistance in HCC. 30982500

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Here we tested the P-gp interaction of some A<sub>3</sub> adenosine receptor agonists that are being developed for the treatment of chronic diseases, including rheumatoid arthritis, psoriasis, chronic pain, and hepatocellular carcinoma. 31127007

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Repression of RNA pol III-dependent transcription by chemical inhibition or knockdown of BRF1 RNA pol III transcription initiation factor subunit (BRF1) enhanced HCC cell sensitivity to doxorubicin, suggesting that MAF1 regulates doxorubicin resistance in HCC by controlling RNA pol III-dependent transcription. 31645432

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE We used qRT-PCR to measure expressions of miR-122, β-catenin and MDR1 in four HCC cell lines. 30539797

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE MicroRNA-383 inhibits doxorubicin resistance in hepatocellular carcinoma by targeting eukaryotic translation initiation factor 5A2. 30801960

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE These findings establish a novel miRNA-based approach for autophagy interference to reverse doxorubicin resistance in future chemotherapy regimens against human HCC. 31695022

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE N-Acetyltransferase 10 Enhances Doxorubicin Resistance in Human Hepatocellular Carcinoma Cell Lines by Promoting the Epithelial-to-Mesenchymal Transition. 31354912

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Consequently, P-gp will play an important role in the disposition of cinobufotalin <i>in vivo</i>, which provided a new combination therapy for the clinical treatment of HCC. 31156437

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE These data indicate that the miR-338-5p/EGFR/ABCB1 regulatory loop plays a critical role in HCC, and a negative correlation between miR-338-5p and EGFR or ABCB1 was also detected in HCC clinical samples. 29527329

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE This review outlines the roles and principal mechanisms of p53 and P-gp mediated chemoresistance in HCC. 29772519

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE We tested whether the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydrocarbon receptor, could change the expression of the following liver transporters involved in drug clearance: <i>SLC10A1</i>, <i>SLC22A1</i>, <i>SLC22A7</i>, <i>SLC47A1</i>, <i>SLCO1B1</i>, <i>SLCO1B3</i>, <i>SLCO2B1</i>, <i>ABCB1</i>, <i>ABCB11</i>, <i>ABCC2</i>, <i>ABCC3</i>, <i>ABCC4</i>, <i>ABCC6</i>, and <i>ABCG2</i> We showed that IS increases the expression and activity of the efflux transporter P-glycoprotein (P-gp) encoded by <i>ABCB1</i> in human hepatoma cells (HepG2) without modifying the expression of the other transporters. 29222397

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE FSCN‑1 increases doxorubicin resistance in hepatocellular carcinoma through promotion of epithelial-mesenchymal transition. 29568938

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE MicroRNA-760 Inhibits Doxorubicin Resistance in Hepatocellular Carcinoma through Regulating Notch1/Hes1-PTEN/Akt Signaling Pathway. 29968951

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE All of these results indicate that Baicalein can reverse P-gp-mediated MDR in HCC and may thus be useful for the treatment of drug-resistant HCC. 29571250

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE P-glycoprotein or membrane pump induced drug efflux and altered prosurvival Bcl-2 expression are key mechanisms for drug resistance leading to failure of chemotherapy in HCC. 29208281

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Using in vitro assays, we show that repeated miRNA treatments resulted in gradual reduction of HCC cell proliferation and reversal of doxorubicin resistance. 29758233

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression BEFREE Multidrug resistance (MDR) due to overexpression of MDR1 is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). 29563873

2018

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Previous researches indicated that cyclooxygenase-2 (Cox-2) might be involved in P-glycoprotein (P-gp)-mediated multidrug resistance in hepatocellular carcinoma cells. 28342979

2017

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Connexin 32 affects doxorubicin resistance in hepatocellular carcinoma cells mediated by Src/FAK signaling pathway. 28968929

2017

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE CDKN2B is critical for verapamil-mediated reversal of doxorubicin resistance in hepatocellular carcinoma. 29299129

2017

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Long Noncoding RNA lncARSR Promotes Doxorubicin Resistance in Hepatocellular Carcinoma via Modulating PTEN-PI3K/Akt Pathway. 28464252

2017

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker BEFREE Multidrug resistance (MDR) due to overexpression of P-glycoprotein (P-gp) is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). 28769563

2017