Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C3826128
Disease: Infection in children
Infection in children
0.020 GeneticVariation BEFREE Mannose-binding lectin gene polymorphism and chronic hepatitis B infection in children. 25843194

2016

Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C3826128
Disease: Infection in children
Infection in children
0.020 Biomarker BEFREE Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. 11530147

2001

Entrez Id: 406987
Gene Symbol: MIR204
MIR204
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 Biomarker BEFREE The present study demonstrated that MMP9 expression in pulp tissues, blood and saliva from children with pulpitis and Hp infection in the stomach was upregulated, while miR-204 expression was downregulated. miR-204 may affect inflammatory processes and other oral diseases in children with pulpitis and Hp infection via MMP9, and may be a potential marker for the detection of Hp infection in children with pulpitis. 31258660

2019

Entrez Id: 27163
Gene Symbol: NAAA
NAAA
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 Biomarker BEFREE Low LYM*PLT and high MPV/PLT may indicate influenza A infection in children with influenza-like symptoms, which can be a useful indicator for diagnosis and differentiation of influenza A infection. 31420904

2019

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE The objectives of the study were to evaluate the associations between both TLR4 rs4986790 and rs4986791 gene polymorphisms and H. pylori infection in children with gastritis. 31690518

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 AlteredExpression BEFREE The present study demonstrated that MMP9 expression in pulp tissues, blood and saliva from children with pulpitis and Hp infection in the stomach was upregulated, while miR-204 expression was downregulated. miR-204 may affect inflammatory processes and other oral diseases in children with pulpitis and Hp infection via MMP9, and may be a potential marker for the detection of Hp infection in children with pulpitis. 31258660

2019

Entrez Id: 1755
Gene Symbol: DMBT1
DMBT1
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 AlteredExpression BEFREE To our knowledge, this is the first study on the relationship between PM<sub>2.5</sub> exposure and innate airway antimicrobial activity in children, in an e-waste area, showing that PM<sub>2.5</sub> pollution may weaken airway antimicrobial activity by down-regulation of saliva SAG levels, which might accelerate airway pathogen infection in children. 30622078

2019

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE The aim of this study was to investigate whether there is an association between the use of TNFα inhibitors and the risk of serious infection in children with IBD. 31494100

2019

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 AlteredExpression BEFREE Pruritus ani, normal WBC count, normal neutrophil count, and normal CRP level at presentation could predict EV infection in children who present with right iliac fossa pain. 29664657

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 Biomarker BEFREE The use of interferon gamma (IFN-γ) release assays (IGRAs) for the diagnosis of tuberculosis (TB) infection in children is still under debate because of concerns about the immature immune response in children. 29142046

2018

Entrez Id: 85480
Gene Symbol: TSLP
TSLP
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 Biomarker BEFREE Our aim was to study the epidemiology and clinical manifestations of human metapneumovirus (hMPV) infection in children in the Suzhou area, China, and to investigate the effect of thymic stromal lymphopoietin (TSLP) on wheezing in hMPV-infected children. 27357989

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 Biomarker BEFREE Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment. 29059186

2017

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE IL-8 -251A/T and +781C/T SNPs are associated with susceptibility to renal parenchymal infection in children and could be implicated in APN risk. 28716390

2017

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. 28746216

2017

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE IL-8 -251A/T and +781C/T SNPs are associated with susceptibility to renal parenchymal infection in children and could be implicated in APN risk. 28716390

2017

Entrez Id: 6279
Gene Symbol: S100A8
S100A8
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 Biomarker BEFREE A partial recombinant CagA protein containing epitope regions (683-749 amino acids), which were identified in this study, was produced and used for the detection of anti-CagA antibodies and further investigated its serodiagnostic value for determination of H. pylori infection in children. 28934419

2017

Entrez Id: 5047
Gene Symbol: PAEP
PAEP
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 Biomarker BEFREE Combined treatment with pegylated interferon (PEG-IFN)-α2b and ribavirin (RBV) is the only currently approved treatment for hepatitis C virus (HCV) infection in children. 26406390

2016

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE We examined the associations of IL2 and IL4 polymorphisms and expression with the risks of asthma and M. pneumoniae infection in children. 25747600

2015

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE We examined the associations of IL2 and IL4 polymorphisms and expression with the risks of asthma and M. pneumoniae infection in children. 25747600

2015

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE The purpose of the present review is to summarise the current knowledge on the association between single nucleotide polymorphisms (SNPs) in the interferon L3 (IFNL3) gene and hepatitis C virus (HCV) infection in children. 25071317

2014

Entrez Id: 84896
Gene Symbol: ATAD1
ATAD1
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE The aim of this study was to determine the genetic diversity of Plasmodium falciparum by analyzing the polymorphism of the msp-1 and msp-2 genes and the multiplicity of infection in children with uncomplicated malaria in southern Benin. 24135216

2013

Entrez Id: 89782
Gene Symbol: LMLN
LMLN
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE Variant transcending IgG antibodies to MSP-119 are associated with protection from infection in children, but not adults. 22909378

2012

Entrez Id: 4485
Gene Symbol: MST1
MST1
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE Variant transcending IgG antibodies to MSP-119 are associated with protection from infection in children, but not adults. 22909378

2012

Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE Variant transcending IgG antibodies to MSP-119 are associated with protection from infection in children, but not adults. 22909378

2012

Entrez Id: 84000
Gene Symbol: TMPRSS13
TMPRSS13
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE Variant transcending IgG antibodies to MSP-119 are associated with protection from infection in children, but not adults. 22909378

2012