Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Efficient engagement with the envelope glycoprotein membrane-proximal external region (MPER) results in robust blocking of viral infection by a class of broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV). 31787208

2020

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Attachment of envelope glycoprotein gp120 to the host cell receptor CD4 is the first step during the human immunodeficiency virus-1 (HIV-1) entry into the host cells that makes it a promising target for drug design. 31792886

2020

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE In addition to these anti-cancer properties, man-specific seaweed lectins have been widely used as potent human immunodeficiency virus (HIV-1)-inactivating proteins, due to their capacity to specifically interact with the envelope glycoprotein gp120 and prevent the virion infectivity of HIV-1 towards the host CD4+ T-lymphocyte cells in vitro. 31357490

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Neutralizing antibodies against human immunodeficiency virus subtype 1 (HIV-1) bind to its envelope glycoprotein (Env). 31607367

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE The envelope glycoprotein gp120 is exposed on the surface of the HIV envelope, essential for virus entry into cells by the attachment to specific cell surface receptors. 30873925

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation BEFREE The N-terminal fusion peptide (FP) of the human immunodeficiency virus (HIV)-1 envelope glycoprotein (Env) gp41 subunit plays a critical role in cell entry. 30770829

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have been shown to protect non-human primates (NHPs) against chimeric simian-human immunodeficiency virus (SHIV) infection. 31513771

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE PF-68742 is a small molecule that inhibits the infection of a subset of HIV-1 strains by interfering with an Env function other than receptor binding. 31391272

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE The SOS change exerted more subtle, context-dependent effects on Env conformation and function.<b>IMPORTANCE</b> The human immunodeficiency virus type 1 (HIV-1) envelope proteins (Envs) bind receptors on the host cell and change shape to allow the virus to enter the cell. 30944182

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer undergoes a sequence of conformational changes triggered by both CD4 and coreceptor engagement. 30650070

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation BEFREE Binding to the receptor CD4 triggers entry-related conformational changes in the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, (gp120/gp41)<sub>3</sub> Soluble versions of HIV-1 Env trimers (sgp140 SOSIP.664) stabilized by a gp120-gp41 disulfide bond and a change (I559P) in gp41 have been structurally characterized. 30429345

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Human immunodeficiency virus (HIV-1) entry is initiated by the binding between the viral envelope glycoprotein gp120 and the host receptor CD4, and followed by reduction of structural disulfides of gp120 and CD4. 30948772

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE An envelope glycoprotein, gp41, is crucial for the entry of human immunodeficiency virus (HIV) into the host cell. 31345037

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE In addition, the molecular docking of virus-entry molecule (gp120 envelope glycoprotein) revealed the key interacting residues of the protein (cellular receptor, CD4) and the site-moiety preferences of colchicine derivatives as HIV entry inhibitors for binding to HIV structure. 30251609

2019

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE The gp41 transmembrane domain of the envelope glycoprotein of the human immunodeficiency virus (HIV) modulates the conformation of the viral envelope spike. 30199809

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation BEFREE Comparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers. 29618643

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation BEFREE The results presented here suggest that the SOSIP changes stabilize Env in a conformation that differs from State 1 but also from the downstream Env conformations stabilized by L193R or I423A.<b>IMPORTANCE</b> The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer is triggered by receptor binding to mediate the entry of the virus into cells. 30021898

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Small-molecule CD4-mimetic compounds (CD4mc) inhibit human immunodeficiency virus (HIV-1) entry by blocking binding to the CD4 receptor and by premature triggering of the viral envelope glycoprotein (Env) spike. 29617845

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Entry of human immunodeficiency virus type 1 (HIV-1) into host cells is mediated by conformational changes in the envelope glycoprotein (Env) that are triggered by Env binding to cellular CD4 and chemokine receptors. 29875245

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE We have previously reported that the CBD1 peptide (SLEQIWNNMTWMQWDK), corresponding to the consensus caveolin-1 binding domain in human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp41, elicits peptide-specific antibodies. 29976675

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE CD4mc should increase the protective efficacy of any HIV-1 Env vaccine that elicits antibodies against CD4-induced conformations of Env. 29915222

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE In this study, we analyzed the effect of the HIV envelope glycoprotein gp120 on GBM cell proliferation. 30200472

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE VRC01 broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4<sub>BS</sub>) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env). 30403372

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE Human immunodeficiency virus (HIV) envelope glycoprotein (glycoprotein 120, gp120) can induce chronic neuropathic pain by directly stimulating primary sensory afferent neurons. 28827078

2018

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker BEFREE The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) encodes specific trafficking signals within its long cytoplasmic tail (CT) that regulate incorporation into HIV-1 particles. 29212940

2018