|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019).
|
30009173 |
2018 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
No association was detected between HLA-DPB1 alleles and cervical cancer risk in the Japanese population.
|
27193219 |
2016 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
We investigated whether polymorphisms in the HLA-DPB1 gene were associated with cervical cancer risk in a Taiwanese population.
|
26031576 |
2015 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
Our study provides the first systematic investigation of the association of genetic variants in the HLA-DP region with cervical cancer susceptibility and provides further insight into the contribution of polymorphisms in the HLA-DP region to risk of cervical cancer.
|
24743517 |
2014 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
GWASDB |
We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75).
|
23817570 |
2013 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
Biomarker |
CTD_human |
We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75).
|
23817570 |
2013 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
The results illustrate the value of pathway-based analysis to mine genome-wide data, and point to the importance of the MHC region and specifically the HLA-DPB1 locus for susceptibility to cervical cancer.
|
21716314 |
2011 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
D6S2766 and D6S2764, which are located near to the region containing the HLA-DPB genes, were negatively related with cervical cancer (OR for the D6S2766-195 allele carriers = 0.50), and positively related with cervical cancer (OR for the D6S2764-209 allele carriers = 2.44), respectively.
|
18712835 |
2008 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
Biomarker |
BEFREE |
These results indicate that HLA-DPB1*1301 may confer susceptibility to cervical cancer, and the haplotypes DRB1*150101-DQB1*0602 and DRB1*070101-DQB1*0201 may contribute to the resistance to the development of cervical cancer among Chinese women.
|
17349874 |
2007 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
Additionally, as for the HPV16 E6 prototype-positive cervical cancers, a significant positive association was found in DQB1*060101 allele (OR=5.95; P=0.002; Pc=0.036), and similar trends were observed for DQB1*030201 (OR=10.87, P<0.0001; Pc=0.0018), and DPB1*1301(OR=7.40, P=0.002; Pc=0.04).
|
17311339 |
2007 |
|
HLA-DPB1
|
cervical cancer
|
0.500 |
GeneticVariation |
BEFREE |
The strongest class II effects are coming from the DQB1 and DRB1 loci, but the DPB1 locus also contributes to the susceptibility to cervical cancer.
|
15238505 |
2004 |