Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 GeneticVariation BEFREE The liver kinase B1 (LKB1) gene is a tumor suppressor associated with the hereditary Peutz-Jeghers syndrome and frequently mutated in non-small cell lung cancer and in cervical cancer. 30222967

2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 GeneticVariation BEFREE However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. 27546620

2017
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 Biomarker BEFREE Heightened and sustained receptor activation was demonstrated by LKB1-deficient A549 (lung) and HeLaS3 (cervical) cancer cell lines. 24285539

2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 AlteredExpression BEFREE Gene expression profiles of cervical cancer HeLa cells stably expressing LKB1 were analyzed by microarray. 24792998

2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 Biomarker BEFREE Mir-155 promotes cervical cancer cell proliferation through suppression of its target gene LKB1. 25155037

2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 AlteredExpression BEFREE LKB1 expression and the integrity of LKB1-AMPK signaling were determined with immunoblot in 6 cervical cancer cell lines. 22735790

2012
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 GeneticVariation BEFREE Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer. 21926085

2011
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 AlteredExpression BEFREE Thus, homozygous deletions affecting LKB1 in cervical cancers may generate multiple fusion transcripts involving LKB1, SBNO2, and c19orf26. 20193846

2010
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 GeneticVariation BEFREE Somatic LKB1 mutations promote cervical cancer progression. 19340305

2009
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 Biomarker BEFREE The LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas (NSCLCs) and cervical cancers. 19724060

2009
Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 GeneticVariation UNIPROT

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.500 Biomarker HPO