Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients. 31756773

2020

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation BEFREE New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma. 30664963

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression BEFREE The present study evaluated the effect of ethanolic extract of <i>Nardostachys jatamansi</i> roots (NJ<sub>et</sub>) on MYCN mediated regulation of expression of MDM2 and p53 proteins in neuroblastoma cell lines, IMR-32 and SK-N-MC. 28216878

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Oridonin induces Mdm2-p60 to promote p53-mediated apoptosis and cell cycle arrest in neuroblastoma. 31339234

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma. 30536898

2019

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Although MDM2 has been validated as a promising target in preclinical models, no MDM2 inhibitors have yet entered clinical trials for neuroblastoma patients. 29416773

2018

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE In conclusion, these data strongly support the further evaluation of dual BCL2/MDM2 targeting as a therapeutic strategy in neuroblastoma. 28915653

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE The Neuroblastoma New Drug Development Strategy (NDDS) has: 1) established a group with expertise in drug development; 2) prioritised targets and drugs according to tumour biology (target expression, dependency, pre-clinical data; potential combinations; biomarkers), identifying as priority targets ALK, MEK, CDK4/6, MDM2, MYCN (druggable by BET bromodomain, aurora kinase, mTORC1/2) BIRC5 and checkpoint kinase 1; 3) promoted clinical trials with target-prioritised drugs. 28604107

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Together, combined inhibition of ALK and MDM2 may provide an effective treatment for <i>TP53</i> wild-type neuroblastoma with <i>ALK</i> aberrations. 28425916

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression BEFREE Importantly, neuroblastoma maintains both an active p53 and an aberrant mTOR signaling.<b>Experimental Design:</b> Using an orthotopic xenograft model and modulating p53 levels, we investigated the antitumor effects of the mTORC1 inhibitor temsirolimus in neuroblastoma expressing normal, decreased, or mutant p53, both as single agent and in combination with first- and second-generation MDM2 inhibitors to reactivate p53.<b>Results:</b> Nongenotoxic p53 activation suppresses mTOR activity. 28821555

2017

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE In summary, our data strongly suggest that MDM2-specific inhibitors like SAR405838 may serve not only as a stand-alone therapy, but also as an effective adjunct to current chemotherapeutic regimens for treating NB with an intact MDM2-p53 axis. 27764791

2016

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression BEFREE The presence of SNP309 does not affect MDM2 expression in neuroblastoma. 24391119

2014

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Here we establish the role of these conjugates in activating p53 pathway by phosphorylation at Ser15, 20 and 46 residues and downregulate key oncogenic proteins such as MYCN and Mdm2 in IMR-32 neuroblastoma cells. 23992861

2013

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE The role of the MDM2 antagonist, p14(ARF), in controlling the TP53-MDM2 balance in neuroblastoma is unresolved. 23343716

2013

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression BEFREE Our results indicate that MDM2 has a p53-independent role in the regulation of both MYCN mRNA stabilization and its translation, suggesting that MDM2-mediated MYCN expression is one mechanism associated with growth of MYCN-associated neuroblastoma and disease progression. 21822304

2012

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Also, we found that the enforced overexpression of MDM2, or conversely, the inhibition of overexpressed endogenous MDM2, led to either a remarkable increase or decrease in tumor growth, respectively, in MYCN-amplified neuroblastoma (even though no p53 function was involved). 21862876

2011

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression BEFREE MDM2 is a key inhibitor of p53 and a positive activator of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) activity with an important role in neuroblastoma pathogenesis. 21484514

2011

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3. 21460101

2011

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE A cohort of 497 NB children, enrolled in the Italian Neuroblastoma Registry between January 1985 and December 2005 and previously investigated for the prognostic role of MDM2 SNP309, was considered for this study. 20232446

2010

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE Inactivation of the p53/MDM2/p14(ARF) pathway develops during treatment and contributes to neuroblastoma relapse. 20145180

2010

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE To study the interaction of MYCN and MDM2, we generated an Mdm2 haploinsufficient transgenic animal model of neuroblastoma. 19649205

2009

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker BEFREE The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73. 19360352

2009

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 AlteredExpression BEFREE We review here these mechanisms for evasion of p53-mediated growth control and conclude that deregulation of the p14(ARF)-MDM2-p53 axis seems to be the principal mode of p53 inactivation in neuroblastoma, opening new perspectives for targeted therapeutic intervention. 19779493

2009

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation BEFREE MDM2 SNP309, a T-to-G substitution in the MDM2 promoter associated with higher gene expression compared to wild-type, may attenuate the p53 pathway in NB, in which p53 mutations are rare. 19526525

2009

Entrez Id: 4193
Gene Symbol: MDM2
MDM2
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 GeneticVariation BEFREE Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53. 19903807

2009