Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE To determine the association between second-trimester serum Down syndrome screening (alpha-fetoprotein [AFP] free beta-human chorionic gonadotropin [b-hCG] unconjugated estriol [uE3]) and preterm birth and to create predictive models for preterm birth. 30602167

2019

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE To establish gestational age-specific and body weight-specific mid-trimester normal median equations for the prenatal serum markers α-fetoprotein (AFP), free β subunit human chorionic gonadotropin (fβHCG), and unconjugated oestriol (uE3) for a Chinese population; to compare and replace the median equations built in LifeCycle software; to evaluate the effect of equations used for gestation correction on estimating risk in Down's syndrome, Edward's syndrome, and neural tube defect (NTD).A total of 353,065 cases of prenatal screening data of pregnant women were screened by 13 prenatal screening institutions in China. 30170416

2018

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE Therefore, the combination of uE<sub>3</sub>, AFP, and hCG is now widely used for Down Syndrome screening as a triple marker. 29098334

2018

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE Because maternal serum markers (pregnancy-associated plasma protein A, human chorionic gonadotropin free β subunit, and alpha-fetoprotein) used for Down syndrome (DS) screening have been described as predictors of obstetrical complications and because assisted reproductive technology (ART) pregnancies are known to be at increased risk for obstetrical complications, it is unclear whether or not correction factors should be applied to the calculated risk of DS. 28921586

2017

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE A western blot analysis confirmed the LC-ESI-MS/MS data that combined detection of Apolipoprotein A-II (apo A-II) and alpha-fetoprotein (AFP) could be a potential tool for diagnosing DS cases. 20622492

2010

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 GeneticVariation BEFREE We report a new mutation in exon 5 of the AFP gene, leading to a total absence of AFP on 2nd-trimester maternal serum screening for Down syndrome, confirmed on the amniotic fluid. 18854864

2009

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 AlteredExpression BEFREE There are also occasional reports of prenatal diagnosis of IAD by findings on the maternal triple-marker screen (TMST), a combined serum analyte test that measures levels of alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol for the detection of Down syndrome and open neural-tube defects. 16390921

2006

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE Amniocentesis was performed at 18 weeks' gestation because of an increased risk for Down syndrome based on maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening. 16470734

2006

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 AlteredExpression BEFREE Chromosomal analysis showed a normal female karyotype, despite a high estimated risk for Down syndrome suggested by the low maternal serum alpha-fetoprotein level. 15630540

2005

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE The efficiency of six maternal serum markers for Down's syndrome (DS), alpha fetoprotein (AFP), human chorionic gonadotropin (hCG), free beta-hCG, pregnancy-associated plasma protein-A (PAPP-A), the proform of eosinophil major basic protein (ProMBP), pregnancy-specific-beta-1-glycoprotein (SP(1)), and combinations thereof, was examined. 15032969

2004

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE Down's syndrome risks are estimated between 15 and 20 completed weeks' gestation (cGW) using an algorithm involving maternal age and serum alpha-fetoprotein (AFP), chorionic gonadotrophin and unconjugated oestriol levels, each expressed as a multiple of the median level (MoM) at the cGW. 11392497

2001

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 GeneticVariation BEFREE A patient- specific second trimester risk for fetal Down's syndrome was calculated using the median values for AFP, hCG, uE3 and maternal age. 11371107

2001

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 GeneticVariation BEFREE It should also be recognized in AFP screening for neural tube defects or Down's syndrome during pregnancy. 9681083

1998

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE The concentration of maternal alpha-fetoprotein was normal and the risk of Down's syndrome was 1 in 6800. 9819862

1998

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE The risk for Down syndrome at term was calculated from maternal serum hCG and AFP, and maternal age. 7518896

1994

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE Information on maternal age and maternal serum alpha-fetoprotein, unconjugated oestriol (uE3), and human chorionic gonadotrophin (hCG) levels was used to investigate retrospectively the effect of estimating Edward's syndrome risk in women having multi-marker screening for Down's syndrome. 7506408

1993

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE In a previous year in which maternal serum alpha-fetoprotein alone was used, 3.6% had positive screening tests (Down syndrome risk > or = 270); the detection rate for all aneuploidies was one in 57 amniocenteses, and for trisomy 21 it was one in 114. 7694460

1993

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE Significant correlations were found for AFP and UE3 in the controls and for intHCG and F beta HCG in both the control and the Down's syndrome pregnancies. 8284287

1993

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 AlteredExpression BEFREE Variability in predicted rates of Down syndrome associated with elevated maternal serum alpha-fetoprotein levels in older women. 2456690

1988

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 AlteredExpression BEFREE Fetal weight does not seem to account for the lower maternal serum alpha-fetoprotein levels seen in fetuses with Down syndrome but may partially account for the lower levels seen in fetuses with trisomy 18. 2449077

1988

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 AlteredExpression BEFREE The AFP levels were below the median value for the normal pregnancies in 38 of the 44 Down syndrome-affected fetuses. 2446968

1987

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 AlteredExpression BEFREE Maternal age at delivery and serum AFP levels by multiples of the median were used to construct a table to determine the risk of Down syndrome. 2426637

1986

Entrez Id: 174
Gene Symbol: AFP
AFP
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome
0.100 Biomarker BEFREE Maternal serum alpha-fetoprotein screening for autosomal trisomies (mainly Down syndrome) is feasible. 2418684

1986