Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Real-time PCR was used to assess AREG and EREG mRNA expression in metastatic colorectal cancer (CRC) samples from 153 patients. 31519572

2019

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Influence of mRNA expression of epiregulin and amphiregulin on outcome of patients with metastatic colorectal cancer treated with 5-FU/LV plus irinotecan or irinotecan plus oxaliplatin as first-line treatment (FIRE 1-trial). 26284333

2016

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE High EREG and AREG expression, and left-sided primary tumours are associated with superior efficacy of anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (CRC), but a unifying explanation of these findings is lacking. 27272216

2016

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Our results indicate that high AREG and EREG mRNA expression are independent favorable prognostic biomarkers in mCRC. 27344184

2016

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Patients (238 total) with first-line metastatic colorectal cancer (mCRC) were randomized to FOLFOX or FOLFIRI chemotherapy ± cetuximab. qRT-PCR analyses were conducted on tissues from 103 patients at baseline to measure gene expression levels of HER-related genes, including amphiregulin (AREG), betacellulin (BTC), NT5E (CD73), DUSP4, EGF, EGFR, epigen (EPGN), epiregulin (EREG), HBEGF, ERBB2 (HER2), ERBB3 (HER3), ERBB4 (HER4), PHLDA1, and TGFA. 25520391

2015

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Our study indicated that serum levels such as HGF, EREG, and AREG may be significant markers to predict the grade of skin toxicity and the prognosis of anti-EGFR antibody treatment, which contribute to improvement of the management of skin toxicity and survival time in mCRC patients. 25707609

2015

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We studied the EGFR pathway [EGFR, NRAS, BRAF, PIK3CA, phosphatase and tensin homolog (PTEN), amphiregulin (AREG), and epiregulin (EREG)] in 105 patients with mCRC KRAS codon 12 wild type. 26341080

2015

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Intermittent versus continuous erlotinib with concomitant modified "XELOX" (q3W) in first-line treatment of metastatic colorectal cancer: correlation with serum amphiregulin and transforming growth factor alpha. 24114668

2013

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE To investigate the predictive significance of KRAS, BRAF, PIK3CA mutational status, AREG- EREG mRNA expression, PTEN protein expression and skin rash in metastatic colorectal cancer (mCRC) patients treated with cetuximab containing salvage chemotherapy. 21283802

2011

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. 19738126

2009

Entrez Id: 374
Gene Symbol: AREG
AREG
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. 17664471

2007