Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Collectively, activating PTPase SHP-1 by regorafenib focusing on its anti-EMT activity might be a useful pharmacotherapy for mCRC. 27580057

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Retrospective studies have suggested that phosphatase and tensin homolog (PTEN) expression might predict the efficacy of cetuximab in patients with KRAS wild-type metastatic colorectal cancer (mCRC). 25861836

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. 24595598

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Loss of phosphatase and tensin homologue (PTEN) function evaluated by loss of PTEN protein expression on immunohistochemistry (IHC) has been reported as both prognostic in metastatic colorectal cancer and predictive of response to anti-EGFR monoclonal antibodies although results remain uncertain. 24564252

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE We investigated predictive values of BRAF, PI3K and PTEN in cetuximab responses in KRAS wild-type (+) chemotherapy refractory, metastatic colorectal cancer (CRC) patients. 23996432

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Our data demonstrated the potential utility of alterations in PTEN and MET expression as predictive markers for response to anti-EGFR MoAbs in mCRC patients with KRAS mutations. 24839940

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE These results suggest that BRAF mutations, PIK3CA exon 20 mutations and PTEN loss are predictive of worseoutcomes in KRAS wild-type mCRC treated with anti-EGFR MoAbs [corrected]. 23494461

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The EWG encourages further studies of the potential value of testing in patients with mCRC who were found to have tumors that are wild type (mutation negative) for KRAS to predict responsiveness to therapy.The EWG found insufficient evidence to recommend for or against testing for mutations in NRAS, or PIK3CA, and/or loss of expression of PTEN or AKT proteins. 23429431

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer. 22285706

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Studies were systematically identified to investigate the relationship between PTEN expression and clinical outcome in mCRC patients treated with anti-EGFR MoAbs. 22610356

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. 21163703

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Mutations in KRAS and BRAF genes as well as the loss of expression of phosphatase and tensin homolog (PTEN) (deleted on chromosome 10) are associated with impaired activity of antibodies directed against epidermal growth factor receptor in patients with metastatic colorectal cancer. 20947270

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE To investigate the predictive significance of KRAS, BRAF, PIK3CA mutational status, AREG- EREG mRNA expression, PTEN protein expression and skin rash in metastatic colorectal cancer (mCRC) patients treated with cetuximab containing salvage chemotherapy. 21283802

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE KRAS mutation and PTEN protein expression are significantly correlated with the response rate and survival time of Chinese mCRC patients treated with cetuximab. 21155011

2010

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Here, we present the mutational analysis of PIK3CA and KRAS and evaluation of the PTEN protein status in a cohort of 110 patients with mCRC treated with anti-EGFR moAbs. 19223544

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE A cohort of patients with irinotecan-refractory mCRC who were treated with cetuximab plus irinotecan was tested for PTEN immunoreactivity (ie, immunohistochemistry; IHC), pAKT IHC, and KRAS mutations. 19398573

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE These results support a role for Akt2 overexpression in metastatic colorectal cancer and establish a mechanistic link between Akt2 overexpression and PTEN mutation in metastatic tumor establishment and growth. 19075230

2008

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Secondary malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. 17940504

2007