×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
This study sought to evaluate short-term treatment with COX-2 inhibitors and acute changes in colonic PGE2 levels as predictors of long-term efficacy in a genetic model of colorectal cancer .
31797003 2020
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Therefore, the present study was designed to assess the prophylactic potentials of probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus GG) in conjunction with celecoxib, a selective cox-2 inhibitor in 1,2 dimethylhydrazine dihydrochloride (DMH)-induced experimental colon carcinogenesis, a well-established, well appreciated and widely used model for colorectal cancer that shares many similarities to human sporadic colorectal cancer with respect to response to some promotional and preventive agents.
30183370 2019
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway.
29339153 2019
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer .
31205515 2019
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis.
31614548 2019
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population.
29552755 2019
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
The role of COX-2 expression, especially its posttranscriptional regulation in colorectal cancer , needs further elucidation.
30186819 2018
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Patient databases also delineated the correlation of RIPK3 and COX-2 expression with colorectal cancer survival.
30012671 2018
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer .
29229353 2018
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer .
29068698 2018
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
28786533 2018
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Feces COX-2 mRNA has a high sensitivity for detect colorectal cancer ; combination with FOBT will be the best alternative.
28139497 2017
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
The inhibitory effect induced by RSVL on the COX-2 expression in human colorectal cancer was investigated.
28338176 2017
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer .
29037225 2017
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
FosB transcription factor regulates COX-2 expression in colorectal cancer cells without affecting PGE2 expression.
28454270 2017
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Colorectal cancer is characterized by aberrant Cyclooxigenase-2 (COX-2 ) and β-Catenin pathways.28178650 2017
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
In cell lines, three colorectal cancer cell lines exhibited high expression of COX-2 and 5-LOX.
26707712 2016
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
The presence of the COX-2 -1195AA genotype may protect against risk of developing colorectal cancer .
25835114 2015
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Normal colorectal mucosa and paired cancerous tissue from 60 patients with colorectal cancer was investigated for the levels of COX-2 mRNA by real-time quantitative Polymerase Chain Reaction (qPCR).
24383454 2014
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
This research evaluated risk of association of the SNPs, including genes for COX-2 (A/G transition at +202) and MMP-2 (C/T transition at-1306), with colorectal cancer in 125 patients and 125 healthy controls.
24998576 2014
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.
24733273 2014
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found.
24969885 2014
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
These results imply that miR-1297 has the potential to provide a new approach to colorectal cancer therapy by directly inhibiting Cox-2 expression.
25422199 2014
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Effects of Jianpi Jiedu Recipe on reversion of P-glycoprotein-mediated multidrug resistance through COX-2 pathway in colorectal cancer .
23543356 2014
×
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Interactions between diet, lifestyle and IL10, IL1B, and PTGS2/COX-2 gene polymorphisms in relation to risk of colorectal cancer in a prospective Danish case-cohort study.
24194923 2013