×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Co-Detection of miR-21 and TNF-α mRNA in Budding Cancer Cells in Colorectal Cancer .
30999696 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Expression levels of miR-21 and miR-138 in colorectal cancer and normal adjacent tissues were compared.
30675293 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Taken together, our results provide a novel insight into the role of miR-21 in the development of drug resistance in colorectal cancer .
31505885 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Mechanistically, miR-21 -5p and miR-155-5p were transferred to colorectal cancer cells by MDE and bound to the BRG1 coding sequence, downregulating expression of BRG1, which has been identified as a key factor promoting the colorectal cancer metastasis, yet is downregulated in metastatic colorectal cancer cells.
30401711 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer .
29552756 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
A case-control study including 1147 patients and 1203 controls was performed to evaluate the association of SNPs in miR-21 binding sites and colorectal cancer risk.
30569605 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
SAV1, regulated by microRNA-21 , suppresses tumor growth in colorectal cancer .
30681889 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21 -5p in human colorectal cancer .
29549908 2018
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31.
29928882 2018
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21 -mediated activation of phosphatase and tensin homolog.
30186399 2018
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
MicroRNA-21 (miR-21 ) expression in stromal fibroblastic cells in colorectal cancer is well-documented, whereas miR-21 expression in tumor budding cells (TBCs) is poorly described.30361805 2018
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The ratio of miR-21 /miR-24 as a promising diagnostic and poor prognosis biomarker in colorectal cancer .
30575905 2018
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The role of miRNA-21 and epithelial mesenchymal transition (EMT) process in colorectal cancer .
27672217 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Using miR-21 as a test microRNA, we identified 12 target genes of miR-21 in a human colorectal cancer cell by this approach.
27982722 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MicroRNA-21 (Mir-21 ) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer .28957811 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Our comprehensive systematic review revealed that circulating miR-21 may be suitable as a diagnostic biomarker, while tissue miR-21 could be a prognostic marker for colorectal cancer .
28415652 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Different miR-21 -3p isoforms and their different features in colorectal cancer .
28734015 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Plasma and saliva miR-21 expression in colorectal cancer patients.
27910062 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Current Status and Perspectives Regarding LNA-Anti-miR Oligonucleotides and microRNA miR-21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer .
28401648 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Gender-dependent expression of leading and passenger strand of miR-21 and miR-16 in human colorectal cancer and adjacent colonic tissues.
29355387 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer .
28376502 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4.
28347230 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Direct binding of microRNA-21 pre-element with Regorafenib: An alternative mechanism for anti-colorectal cancer chemotherapy?
28236743 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Expression levels of miR-21 (p<0.0001) and miR-221 (p<0.0001) were significantly higher, whereas expression levels of miR-150 (p=0.0054) were significantly lower in the blood samples of patients with colorectal cancer in comparison to the control group.
27798914 2016
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Further studies are warranted to investigate the molecular mechanisms underlying this novel inhibitor in colorectal cancer to establish its potential value for treatment of CRC patients with high miR-21 expression.
27364574 2016