Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer prognosis: A meta-analysis. 31330573

2019

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer. 31216671

2019

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Low folate status, and MTHFR 677C > T and MTR 2756A > G polymorphisms associated with colorectal cancer risk in Thais: a case-control study. 31740010

2019

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis. 30131855

2018

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer. 29134491

2018

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Polymorphisms of MTHFR C677T and A1298C associated with survival in patients with colorectal cancer treated with 5-fluorouracil-based chemotherapy. 28044213

2017

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis. 29089462

2017

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE MTRR rs1801394 and its interaction with MTHFR rs1801133 in colorectal cancer: a case-control study and meta-analysis. 28691890

2017

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Analyses of KRAS mutations in metastatic colorectal cancer, EGFR mutations in advanced non-small cell lung cancer, CYP2D6 polymorphism in breast cancer, DPD polymorphism in colorectal cancer and MTHFR polymorphism in osteosarcoma have been performed by real time polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP). 27837635

2017

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians, and MTHFR A1298C polymorphism is associated with decreased colorectal cancer risk in Asians. 26156333

2016

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We found that the MTHFR C677T polymorphism was associated with colorectal cancer (P<0.04) but not with gastric cancer. 27823653

2016

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Meta-Prediction of MTHFR Gene Polymorphism Mutations and Associated Risk for Colorectal Cancer. 26858257

2016

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans. 26046315

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Evaluation of association studies and meta-analyses of MTHFR gene polymorphisms in colorectal cancer. 25823789

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Overall, no significant association was found between the MTHFR C677T polymorphism and colorectal cancer in Asian populations (for T vs. C: OR=1.03; 95% CI= 0.92-1.5; p= 0.64; for TT vs CC: OR=0.88; 95%CI= 0.74-1.04; p= 0.04; for CT vs. CC: OR = 1.02; 95%CI= 0.93-1.12; p=0.59; for TT+ CT vs. CC: OR=1.07; 95%CI= 0.94-1.22; p=0.87). 26745044

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population. 26081619

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment in Taiwan colorectal cancer. 26111049

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer. 26564107

2015

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Effects of MTHFR genetic polymorphisms on toxicity and clinical response of irinotecan-based chemotherapy in patients with colorectal cancer. 24611457

2014

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects. 24193867

2014

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are associated with colorectal cancer risk in the Turkish population. 25292054

2014

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE The MTHFR 677 C>T variant genotypes are significantly associated with increased risk of colorectal cancer. 23437053

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE We analyzed the impact of MTHFR C677T polymorphism in colorectal cancer in a region of the Tenerife Island whose population has a history of genetic isolation and a low genetic variability. 23422951

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Association between MTHFR polymorphisms and overall survival of colorectal cancer patients in Northeast China. 23392576

2013

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Malignant neoplasm of colon and/or rectum
0.100 GeneticVariation BEFREE Allele and genotype frequencies of the polymorphic methylenetetrahydrofolate reductase and colorectal cancer among Jordanian population. 24083702

2013