Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Anthocyanins Prevent and Inhibit Colorectal Cancer through PI3K/AKT/survivin Signaling Pathway. 31830892

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE FAT4 regulates the EMT and autophagy in colorectal cancer cells in part via the PI3K-AKT signaling axis. 30832706

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer. 30623365

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE In short, COX-2 or 5-LOX deletion and its inhibitors enhanced activity of PTEN and suppressed cell and adenoma progression through PI3K/AKT pathway in colorectal cancer. 29339153

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and survival by inducing cell cycle arrest and PI3K/AKT/mTOR pathway blockage. 31357480

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer. 30472186

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Further, the role of PI3K/Akt/mTOR inhibitors alone and in combination with other chemotherapeutic drugs, in alleviating colorectal cancer is also discussed. 31215384

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE We selected MAPK- and PI3K-pathway inhibition in colorectal cancer as a model system to dissect out mechanisms of resistance. 30905967

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines. 30691487

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE CCR7 high expression leads to cetuximab resistance by cross-talking with EGFR pathway in PI3K/AKT signals in colorectal cancer. 31815051

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE H19 regulates PI3K-Akt signal pathway through a competing endogenous RNA network and predicts poor prognosis in colorectal cancer. 31164794

2019

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Although TANKYRASE (TNKS) inhibitors have been proposed as promising candidates, there are many colorectal cancer models that do not respond positively to TNKS inhibition <i>in vitro</i> and <i>in vivo</i> Therefore, a combinatorial therapeutic approach combining a TNKS inhibitor (G007-LK) with PI3K (BKM120) and EGFR (erlotinib) inhibitors in colorectal cancer was investigated. 29222171

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. 29970122

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer. 29260353

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE uc.338 targets p21 and cyclin D1 via PI3K/AKT pathway activation to promote cell proliferation in colorectal cancer. 29901203

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer. 30129057

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-κB pathway in colorectal cancer. 29277893

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Pathway analysis revealed multiple pathways including Jak-STAT, TGF-beta, PI3K-Akt and MAPK signaling pathway that are correlated to colorectal cancer. 29496555

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer. 30636581

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer. 29068474

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 AlteredExpression BEFREE Previously, we showed that activation of PI3K/Akt/mTOR contributes to colorectal cancer growth and metastasis. 29666061

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies. 29422975

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer. 29496520

2018

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE Furthermore, PLD1 inhibition suppressed growth of colorectal cancer activated by the Wnt/β-catenin and PI3K signaling pathways.<b>Conclusions:</b> These results suggest that PLD1 linked to ICAT mediates molecular crosstalk between the Wnt/β-catenin and PI3K/Akt pathways and thus could be proposed as a novel colorectal cancer prognostic biomarker. 28939743

2017

Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE These results suggest that regulation of the apoptosis, invasion and migration of colorectal cancer cells by GRA might be through suppressing PI3K and STAT3 signaling pathways. the present study indicated that GRA could be a potential effective therapy for patients with colorectal cancer. 28656212

2017