Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C4725671
Disease: High-Risk Neuroblastoma
High-Risk Neuroblastoma 		0.020 Biomarker BEFREE Key regulatory pathways including the PI3K/Akt, mTOR and NF-κB are implicated in the pathogenesis of NB. 29581860

2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
CUI: C4725671
Disease: High-Risk Neuroblastoma
High-Risk Neuroblastoma 		0.020 Biomarker BEFREE These data suggest integrin α<sub>v</sub>β<sub>3</sub>, MYCN/BRD4 and PTEN/PI3K/AKT signaling as biomarkers and hence therapeutic targets in neuroblastoma and support testing of the RGD integrin α<sub>v</sub>β<sub>3</sub>-targeted PI-3K/BRD4 inhibitor, SF1126 as a therapeutic strategy in this specific subgroup of high risk neuroblastoma. 28881723

2017