Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 Biomarker BEFREE Disturbances of brain glucose uptake, glucose tolerance, glucose utilization and of the insulin/insulin receptor signaling cascade are thought to be key features of the pathophysiology of AD. 26268335

2016

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 AlteredExpression BEFREE Since IR expression is diminished in type-2 diabetes as well as in Alzheimer's disease (AD) patients, these data may provide a mechanistic link between insulin resistance, impaired synaptic transmission and cognitive decline in humans with metabolic disorders. 22661254

2013

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 Biomarker BEFREE Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. 22057897

2013

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 AlteredExpression BEFREE These results demonstrate that LRP1 mediates anti-apoptotic function in neurons by regulating insulin receptor and the Akt survival pathway and suggest that restoring LRP1 expression in Alzheimer disease brain might be beneficial to inhibiting neurodegeneration. 19815552

2009

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 Biomarker BEFREE The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease. 19519303

2009

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 AlteredExpression BEFREE The study supports the hypothesis that an impaired control of glycogen synthase kinase-3beta activity by insulin receptor-mediated signalling plays a role in the pathogenesis of AD, facilitating tau protein phosphorylation and neurofibrillary tangle formation. 17986027

2008

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 Biomarker BEFREE Cross-species microarray analysis with the OSCAR system suggests an INSR->Pax6->NQO1 neuro-protective pathway in aging and Alzheimer's disease. 17545194

2007

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 Biomarker BEFREE Defective insulin receptor signalings are associated with the dementia in normal aging and patients with age-related neurodegenerative diseases (e.g., Alzheimer's disease); the cognitive impairment can be reversed with systemic administration of insulin in the euglycemic condition. 16210778

2006

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.590 Biomarker BEFREE We investigated the effect of Abeta peptides on insulin binding to the insulin receptor because it is known that (1) Abeta and insulin are both amyloidogenic peptides sharing a common sequence recognition motif, (2) Abeta and insulin are substrates for the same insulin degrading enzyme, and (3) impaired glucose metabolism is a characteristic event in the pathology of AD. 12006603

2002