Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls. 28789839

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Genetic variants of TREM2 (triggering receptor expressed on myeloid cells 2), a cell-surface receptor expressed selectively in myeloid cells, greatly increase the risk of AD, implicating microglia and the innate immune system as pivotal factors in AD pathogenesis. 28442216

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 AlteredExpression BEFREE DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease. 28412600

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and innate immunity in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. 28855300

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration. 28483841

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant. 28855301

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Recently, variants in TREM2 were also associated with frontotemporal dementia and Alzheimer's disease. 28716534

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other neurodegenerative diseases (NDDs). 28768545

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 28714976

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression. 27939925

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Heterozygous triggering receptor expressed on myeloid cells (TREM2) mutations are an Alzheimer's disease (AD) risk factor. 28365005

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. 28802038

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. 28320424

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE TREM2 Function in Alzheimer's Disease and Neurodegeneration. 26854967

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. 27769848

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk for several neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia (FTD). 28559417

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE We analyzed AD risk of TREM2 variants in the NIMH AD Genetics Initiative Study and AD Sequencing Project. 27520774

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. 26911435

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Although TREM2 mutation is reported to be related to Nasu-Hakola disease and Alzheimer's disease, little is known about the association between TREM2 and gliomas. 26506595

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 AlteredExpression BEFREE TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia. 26332043

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. 26758262

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Our data demonstrate that apoE-TREM2 interaction in microglia plays critical roles in modulating phagocytosis of apoE-bound apoptotic neurons and establish a critical link between two proteins whose genes are strongly linked to the risk for AD. 26374899

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE To analyze the association between TREM2 exon 2 variants and late-onset (sporadic) Alzheimer's disease (AD) in an elderly Iranian population. 26021840

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE TREM2 variants and risk of Alzheimer's disease: a meta-analysis. 26037549

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk. 26058841

2016