Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. 28720165

2018

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE The brain-derived neurotrophic factor (BDNF) interacts with important genetic Alzheimer's disease (AD) risk factors. 28322202

2018

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Conditional Depletion of Hippocampal Brain-Derived Neurotrophic Factor Exacerbates Neuropathology in a Mouse Model of Alzheimer's Disease. 28266222

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE To examine the influence of the brain-derived neurotrophic factor (<i>BDNF</i>) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether β-amyloid (Aβ) burden plays a moderating role in this relationship. 28468845

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE MicroRNA-613 regulates the expression of brain-derived neurotrophic factor in Alzheimer's disease. 27545218

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE Sex Differences in Risk for Alzheimer's Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study. 28498887

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE MicroRNA-206, which suppresses the expression of brain-derived neurotrophic factor, is known to be elevated in the brains of Alzheimer's disease (AD) patients. 26842588

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE Female-specific effect of the BDNF gene on Alzheimer's disease. 28202203

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Taken together, TIIA repairs hippocampal LTP and memory, likely, through facilitating the clearance of AD-related proteins and activating synaptic BDNF synthesis. 27274990

2017

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE However, it is unknown whether AD-type neuropathology, soluble Aβ and tau, or levels of BDNF and its receptor tropomyosin-related kinase B (TrkB) correlate with dementia in the oldest-old. 26410307

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Associations Between ApoEε4 Carrier Status and Serum BDNF Levels--New Insights into the Molecular Mechanism of ApoEε4 Actions in Alzheimer's Disease. 24986007

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Higher brain BDNF expression is associated with slower cognitive decline and may also reduce the deleterious effects of AD pathology on cognitive decline. 26819457

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and Therapy. 25354497

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Our data suggest that the interaction of BDNF and APOE has significant effect on AD. 25853819

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer's Disease. 26138246

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE The mild cognitive impairment/Alzheimer's disease cohort showed a longitudinal decline in entorhinal thickness in BDNF Met carriers compared to Val/Val in APOE E4 carriers, with effect sizes ranging from medium to large. 26923413

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Correlation analysis revealed that the expression of miR-29c was positively correlated with BDNF and negatively correlated with DNMT3 protein in the CSF of patients with AD. 25815896

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Transplantation of as-miR-937-expressing MSCs significantly reduced the deposition of Aβ, increased the levels of BDNF, and significantly improved the appearance in SR and PM-DAT in AD mice. 26316079

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 PosttranslationalModification BEFREE Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease. 25484286

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE Measures of the BDNF genotype, plasma BDNF, MRI-based hippocampal volume, and memory performance were obtained from the Knight Alzheimer Disease Research Center (ADRC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). 25784293

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer's disease. 26339337

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. 25288138

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ. 25954034

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE In Alzheimer's disease, accumulation of amyloid-β (Aβ) is associated with loss of brain-derived neurotrophic factor (BDNF), synapses, and memory. 26025137

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease. 25026432

2015