Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE To investigate whether microRNA-19a can promote the proliferative and migratory abilities of non-small cell lung cancer (NSCLC) cells by target inhibition of PTEN (phosphatase and tensin homolog deleted from chromosome 10, PTEN) expression, thus leading to the development of NSCLC. 31424647

2020

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE Our study demonstrates that miR-561 inhibits NSCLC cell proliferation and G1-S transition and induces apoptosis through suppression of the PTEN/AKT signaling pathway by targeting P-REX2a. 31711559

2020

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE <b>Conclusion:</b> Taken together, we proved that miR-224 might play essential roles in cellular functions of nutrient-depleted A549 cells possibly through regulating the target PTEN and downstream signal PI3K, suggesting the potential of miR-224 to be a therapeutic target for NSCLC therapy. 31190892

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE We first found that higher TG2 expression level and lower PTEN and IκBα expression levels in the intrinsic EGFR-TKI resistant NSCLC compare with EGFR-TKI sensitive NSCLC. 31497352

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE Our results indicated that LINC00702 modulated the expression of PTEN gene by acting as a ceRNA for miR-510 in NSCLC. 30840927

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE Finally, rescue experiments were conducted to assess the involvement of PTEN in the development of NSCLC. 31695021

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE Moreover, LINC00342 promoted proliferation by inhibiting the expression of p53 and PTEN proteins in NSCLC cell lines. 30320899

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE The results revealed that compared with normal control cells, PTEN levels were significantly decreased in NSCLC cell lines (P<0.01). 30655903

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE MAGI2-AS3 is downregulated in NSCLC.Overexpression of MAGI2-AS3 suppresses the proliferative and invasive abilities of NSCLC via miRNA-23a-3p/PTEN axis. 31539127

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE Regulation of miR-4262 and PTEN expressions in NSCLC was conducted by transfection. 31337279

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE The present findings suggested that treatment with pemetrexed may exhibit synergistic effects with PTEN on lung cancer cells via the inhibition of the PI3K/AKT/mTOR signaling pathway and through carbohydrate metabolism, and treatment with pemetrexed combined with PTEN overexpression may represent a novel therapeutic strategy for the treatment of NSCLC. 31485626

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE We have conducted this study to check the effect of VCN-2 on the cell viability and the effect on PTEN (Phosphatase and tensin homolog), PI3KCA (Phosphatidylinositol 4, 5-biphosphate 3-kinase catalytic subunit alpha isoform/PI3K 110α subunit), and Akt1 when VCN-2 was used alone and in combination with radiation in the NSCLC cell line NCI-H23 (H23). 30496626

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE The expression of miR-21 in tumor cell lines and clinical NSCLC tumor samples was positively correlated with hypoxia-inducible factor-1α and negatively correlated with PTEN. 30881046

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE Further, we demonstrated that SIRT3 promoted degradation of P53 in PTEN-deficient NSCLC cell lines via the ubiquitin-proteasome pathway. 29103158

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE We firstly indicated that miR-4299 may be a candidate independent marker for NSCLC prognosis and suppressed the progression of NSCLC by modulating the activation of PTEN/AKT/PI3K signaling pathway, suggesting that miR-4299 could be a potential target for developing therapies in treating NSCLC. 29917192

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 GeneticVariation BEFREE In this study, we showed that YM155 markedly enhanced the sensitivity of erlotinib to EGFR-TKI resistant NSCLC cell lines H1650 (EGFR exon 19 deletion and PTEN loss) and A549 (EGFR wild type and KRAS mutation) through inducing autophagy-dependent apoptosis and autophagic cell death. 30315932

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. 30214545

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE Inversely, increased miR-374a was an unfavorable factor when targeting PTEN in more advanced staged NSCLC patients. 29362431

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE In total 50 plasma samples from patients newly diagnosed with advanced NSCLC or resistant to first-line tyrosine kinase inhibitors (TKIs) were subjected to deep sequencing on a seven-gene panel (BRAF, EGFR, ERBB2, KRAS, NRAS, PIK3CA, PTEN) incorporated with molecular barcodes to improve accuracy in variant detection. 30268455

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE Therefore, our study demonstrated that miR-142-5p regulated CD4+ T cells in human NSCLC through PD-L1 expression via the PTEN pathway. 29767245

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE qRT-PCR analysis was used to detect the expression of TP53TG1, miR-18a and PTEN mRNA in NSCLC tissues and cells. 29588850

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE miR-486-5p functions as an oncogene by targeting PTEN in non-small cell lung cancer. 29567332

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 Biomarker BEFREE Moreover, upregulation of miR-584 was involved in the regulation of the phosphatase and tensin homolog/Akt serine/threonine kinase signalling pathway in NSCLC. 29434826

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 AlteredExpression BEFREE Further, we showed that the LNA treatment rescues PTEN expression in non-small-cell lung cancer (NSCLC) cells, which is suppressed by the elevated level of miRNA 92b. 29529863

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.500 GeneticVariation BEFREE To the best of our knowledge, this is the first case of NSCLC harboring concurrent PTEN and TP53 mutations with widespread and strong coexpression of TTF-1 and p40, which has been confirmed in the resected specimen, and only the second documented case of NSCLC with TTF-1 and p40 diffuse coexpression in the carcinoma cells from the same individual. 29410129

2018