Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Differential Efficacy of Anti-VEGF Antibodies Based on Sex and Race in a Diverse Cohort of Advanced Nonsquamous Non-Small Cell Lung Cancer. 31764022

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Antiangiogenic strategies, including monoclonal antibodies binding vascular endothelial growth factor (VEGF) or the corresponding receptor and small molecules which inhibit the function of different angio-related tyrosine kinase, produced interesting results in cancer treatments including non-small-cell lung cancer (NSCLC). 31092048

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Three NSCLC tumor models with responses to VEGF inhibitors were designed to determine innate immune-related underpinnings of resistance to anti-angiogenic therapy. 31829270

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Targeting tumor angiogenesis pathway <i>via</i> VEGF siRNA (siVEGF) has shown great potential in treating highly malignant and metastatic non-small cell lung cancer (NSCLC). 31534526

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 AlteredExpression BEFREE Our results showed that CyH significantly inhibited angiogenesis <i>in vitro</i> and <i>in vivo</i>, and suppressed the hemoglobin content and HIF-1α and VEGF protein expression in xenografted NSCLC tissues of nude mice. 31205560

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE <b>Introduction:</b> Mesenchymal epidermal transition and vascular endothelial growth factor pathways are important in mediating non-small cell lung cancer (NSCLC) tumorigenesis and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance. 30915273

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 AlteredExpression BEFREE The immunohistochemical analyses demonstrated that there was a significant correlation between IMP3 and VEGF-A expression in NSCLC (r=0.181; P=0.041). 31611984

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 AlteredExpression BEFREE Patients with NSCLC that overexpressed AMPK α1 and VEGF had the worst outcomes. 30988808

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor A (VEGF-A), was used in combination with traditional chemotherapy as the first line treatment for metastatic colorectal cancer (mCRC), non-small cell lung cancer (NSCLC) and advanced ovarian cancer. 31497360

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 AlteredExpression BEFREE Our findings support the role of chemotherapy with or without VEGF blockade as enhancers of ICI activity in NSCLC. 31741764

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE <b>Introduction</b>: To estimate the efficacy and safety of vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) in combination with chemotherapy for patients with advanced non-small cell lung cancer (NSCLC). 30854085

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE The effects of VEGF and MDSC-s on systemic inflammation appeared to be blunted by COPD in patients suffering from advanced NSCLC. 31090020

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 GeneticVariation BEFREE Safety of combining vascular endothelial growth factor receptor tyrosine-kinase inhibitors with chemotherapy in patients with advanced non-small-cell lung cancer: A PRISMA-compliant meta-analysis. 31169681

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 AlteredExpression BEFREE In NSCLC rats, the expression of miR-199a was substantially decreased (p<0.01), but the expressions of HIF-1α and VEGF were notably raised (p<0.01). 31841190

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 AlteredExpression BEFREE These drugs were selected based on the following: PTX is approved for TNBC; nintedanib combined with docetaxel has shown phase III clinical trial success, albeit in NSCLC; VEGF can act as local immunosuppressive factor; and PD-L1 antibody plus taxane therapy was recently reported to have encouraging phase III trial benefit in TNBC. 30635009

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE In addition, correlation analysis implied a significant positive relationship between the density of IL-9 and VEGF, as well as MVD in human NSCLC tissues. 31352324

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Anlotinib is a novel molecular targeted agent targeting the vascular endothelial growth factor receptor, which differs from the other currently available non-small cell lung cancer (NSCLC) molecular targeted drugs targeting this receptor. 31421224

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 GeneticVariation BEFREE Dual blockade of the EGFR and VEGF pathways in EGFR-mutated metastatic non-small-cell lung cancer (NSCLC) is supported by preclinical and clinical data, yet the approach is not widely implemented. 31591063

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE The present review summarized recent advances in the role of VEGF in the pathogenesis, diagnosis and clinical management of MPE in patients with non‑small cell lung cancer. 29693703

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Enzyme-linked immunosorbent assays (ELISAs) were used to detect the level of vascular endothelial growth factor (VEGF) and IL-8 in NSCLC. 29537214

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE The lack of efficacy associated with anti-EGFL7 combined with standard bevacizumab and chemotherapy in this phase II trial in non-small cell lung carcinoma is consistent with the lack of benefit observed in colorectal carcinoma, highlighting the challenge of enhancing the efficacy of VEGF inhibition in unselected populations.Future efforts with agents like anti-EGFL7 should be guided by advances in pharmacodynamic and predictive biomarker development for antiangiogenic agents. 29438092

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE <b>Results:</b> Patients with NSCLC had significantly higher serum concentration of VEGF, compared to those with benign pulmonary nodules and healthy controls (P <0.0001). 29760791

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Evidences suggested that combined blockade of the VEGF and EGFR pathways can improve the treatment efficacy of non-small-cell lung cancer (NSCLC). 29108922

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Vascular endothelial growth factor (VEGF) plays a key role in advanced NSCLC. 29515799

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.400 Biomarker BEFREE Our study suggested that serum levels of HGF, IL-6 and VEGF and its dynamic change during TKI treatment could be used to predict the efficacy of EGFR-TKIs treatment in patients with EGFR-mutant NSCLC. 30429024

2018