Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 688
Gene Symbol: KLF5
KLF5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.640 AlteredExpression BEFREE Further, high KLF5 expression was observed in BRAF-mutant colorectal cancer. 30478887

2019

Entrez Id: 688
Gene Symbol: KLF5
KLF5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.640 GeneticVariation BEFREE These findings raise a potentially oncogenic role for the P301S KLF5 mutant in colorectal cancer. 24398687

2014

Entrez Id: 688
Gene Symbol: KLF5
KLF5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.640 Biomarker BEFREE Given that activation of the Wnt/β-catenin pathway is the most frequently altered pathway in human colorectal cancer, our results argue that KLF5 acts as a fundamental core regulator of intestinal oncogenesis at the stem-cell level, and they suggest KLF5 targeting as a rational strategy to eradicate stem-like cells in colorectal cancer. 24626089

2014

Entrez Id: 688
Gene Symbol: KLF5
KLF5
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.640 AlteredExpression BEFREE Both of these compounds, and two newly synthesized structural analogs of CID 5951923, significantly reduced endogenous KLF5 protein levels and decreased viability of several colorectal cancer cell lines without any apparent impact on IEC-6 cells. 21885866

2011