Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Three adult glioma risk variants, rs634537, rs2157719, and rs145929329, all mapping to the 9p21.3 (<i>CDKN2B-AS1</i>) locus, were associated with glioma risk in children and AYA. 31040135

2019

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). 23161787

2013

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE In analyses including glioma cases with a family history of brain tumours (n = 104) and control subjects free of glioma at baseline, three of seven SNPs were associated with glioma risk: rs2736100 (5p15.33, TERT), rs4977756 (9p21.3, CDKN2A-CDKN2B) and rs6010620 (20q13.33, RTEL1). 23115063

2013

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR). 21825990

2011

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population. 21920947

2011

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). 21742680

2011

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk. 20847058

2010

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk. 20462933

2010

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367

2009

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Beside CDKN2A, other genes (e.g., CDKN2B, and ARF/p14(ARF), long considered distinct from CDKN2A) on this locus are often deleted or mutated in a large number of tumors including glioma, bladder cancer, and lung cancer. 18406873

2008

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 AlteredExpression BEFREE After infection, high levels of p16 and p15 were observed in two human glioma cell lines (U251 MG and U373 MG). 10939591

2000

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE Thus, despite the association between the sporadic forms of high-grade glioma and abnormalities of p16(INK4A), p15(INK4B), or CDK4, we found no evidence that germ-line mutations in the coding region of these three genes predispose to inherited glial tumors. 9815774

1997

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 GeneticVariation BEFREE In order to test the candidacy of p16beta as a glioma suppressor, we replaced p16(INK4a), p15(INK4b) and p16beta wild-type as well as a series of seven glioma-derived p16beta alleles (R87H, A112V, R120H, A121V, G125R, A128A and A128V), into glioma cell lines that had either CDKN2A-/RB+ (U-87MG and U-251MG) or CDKN2A+/RB- (LN-319) endogenous backgrounds and demonstrated that p16beta can act as a functional glioma cell growth suppressor. 9366518

1997

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 Biomarker BEFREE Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma. 7478535

1995

Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
CUI: C0017638
Disease: Glioma
Glioma
0.700 PosttranslationalModification BEFREE These results suggested that inactivation of the CDK4I gene may play an important role in the progression of human glioma. 7775255

1995