Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE While no difference was observed regarding the number of interferon-gamma (IFN-γ)+ cells in lesions from pregnant compared to nonpregnant women with CL, interleukin-10 (IL-10) and IL-4 expression were approximately 3-times higher in lesions in pregnant women. 30165577

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 AlteredExpression BEFREE Circulating plasma IFN-γ levels were also assayed in 400 patients with CL and 400 controls. 31722386

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE Interestingly, IL-8 mRNA levels were significantly higher in ZCL lesions compared to SCL lesions, but interferon-γ was significantly higher in SCL lesions than in ZCL lesions. 30810524

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 AlteredExpression BEFREE Th1 response (IFN-γ and IL-12p40) had higher expression levels compared to Th2 (IL-4) and IL-11 in CL patients. 30642262

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE Cytokine (IL-10, IFN-γ) release patterns of splenocytes and lymph node cell cultures derived from mice primed with experimental infections (with either test or control parasites) revealed significantly high IFN-γ response associated with test mice with CL, while prominent IL-10 levels were observed in association with control mice with VL. 29113609

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE This induced a strong immune response characterized by IFN-γ production at the site of bites and systemically, creating a hostile inflammatory environment for <i>L. major</i> parasites and conferring protection from CL. 30619253

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE In this study, we assessed cell-mediated immunity in non-healing CL through the measurement of three pro-inflammatory cytokines: Interferon-γ (IFN-γ), IL-17a and CXCL-11. 28168727

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 AlteredExpression BEFREE In vitro stimulated ACL PBMCs produced lower levels of IFN-γ (p = 0.0002) and TNF (p <0.0001), and higher levels of IL-10 (p = 0.0006) and IL-17 (p = 0.0008) than CL PBMCs. 27906988

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 AlteredExpression BEFREE Gene Expression Profile of High IFN-γ Producers Stimulated with Leishmania braziliensis Identifies Genes Associated with Cutaneous Leishmaniasis. 27870860

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE Quantitative mRNA studies of the CL lesions showed that accelerated healing was associated with increased Tumour Necrosis Factor-α and Interferon-γ, and reduced Interleukin-10. 21807409

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE Systemic production of TNFα and IFNγ in DL patients is lower than in cutaneous leishmaniasis (CL) caused by L. braziliensis, which may account for parasite dissemination due to the decreased ability to control parasite growth. 21723576

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE CD8+ T cells as a source of IFN-γ production in human cutaneous leishmaniasis. 20967288

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 GeneticVariation BEFREE In conclusion, our results suggest that functional genetic variants in the IL-4 promoter could influence the risk of developing CL while the polymorphism in the first intron of the IFN-gamma gene might influence the progression of disease towards CCL. 16950634

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0023283
Disease: Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous
0.400 Biomarker BEFREE In conclusion, IFNgamma therapy compensates for the parasite-dependent major histocompatibility complex class II downregulation and induces healing of chronic cutaneous leishmaniasis. 12142611

2002