Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
CUI: C0023418
Disease: leukemia
leukemia
0.350 Biomarker BEFREE While expressing weak cytotoxicity on its own, ZW-1288 potentiates the clinical TOP2 inhibitors etoposide (ETP) and mitoxantrone in human prostate DU145 and CCRF-CEM leukemia and chicken lymphoma DT40 cells while not impacting the activity of the topoisomerase I (TOP1) inhibitor camptothecin or the PARP inhibitor olaparib. 31775111

2020

Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
CUI: C0023418
Disease: leukemia
leukemia
0.350 Biomarker BEFREE Furthermore, we examine the involvement of TOP2-induced breaks in the formation of oncogenic translocations of leukemia and papillary thyroid cancer, as well as the role of TOP2 and proteins which repair TOP2 adducts in other diseases. 31614754

2019

Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
CUI: C0023418
Disease: leukemia
leukemia
0.350 GeneticVariation BEFREE We find high TOP2A cleavage levels in genes involved in translocations in TOP2 poison-related leukemia. 28385713

2017

Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
CUI: C0023418
Disease: leukemia
leukemia
0.350 GeneticVariation BEFREE Topoisomerase II (TOP2) targeting drugs like doxorubicin and etoposide are frontline chemotherapeutics for a wide variety of solid and hematological malignancies, including breast and ovarian adenocarcinomas, lung cancers, soft tissue sarcomas, leukemias and lymphomas. 22900064

2012

Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
CUI: C0023418
Disease: leukemia
leukemia
0.350 AlteredExpression BEFREE Previous studies have demonstrated decreased levels of DNA topoisomerase II alpha protein and messenger RNA in the Adriamycin-resistant P388 murine leukemia cell line P388/ADR/7 compared to the sensitive P388/4 cell line. 9494516

1998