Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
CUI: C0025202
Disease: melanoma
melanoma
0.670 Biomarker BEFREE We observed that mutations detected in tumor samples involving genes related to melanoma pathogenesis (TP53, PIK3CA, FGFR3, ATF1, KIT, HRAS and MAP2K2) were present in heterozygosis in the germline status of the patient. 31804055

2019

Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
CUI: C0025202
Disease: melanoma
melanoma
0.670 Biomarker BEFREE phase II and III clinical trials demonstrated modest anti- tumor activity of Binimetinib (MEK162) - a potent allosteric inhibitor of MEK1 and MEK2- in patients with advanced NRAS mutant melanoma. 28919996

2017

Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
CUI: C0025202
Disease: melanoma
melanoma
0.670 GeneticVariation BEFREE Our data confirming that MEK2(C125S), but not the synonymous MEK1(C121S) protein, confers resistance to combination therapy highlight the functional differences between these kinases and the preponderance of MEK2 mutations in combination therapy-resistant melanomas. 25452114

2014

Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
CUI: C0025202
Disease: melanoma
melanoma
0.670 GeneticVariation BEFREE We report a de novo MEK2-Q60P mutation and BRAF gain in a melanoma from a patient who progressed on the MEK inhibitor trametinib and did not respond to the BRAF inhibitor dabrafenib. 24055054

2013

Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
CUI: C0025202
Disease: melanoma
melanoma
0.670 GeneticVariation BEFREE Whole-exome sequencing of seven melanoma cell lines identified overlapping gain of function mutations in MAP2K1 (MEK1) and MAP2K2 (MEK2) genes. 23174022

2013

Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
CUI: C0025202
Disease: melanoma
melanoma
0.670 GeneticVariation BEFREE The purpose of this study was to determine the response rate (RR) for the selective, allosteric MEK1/MEK2 inhibitor trametinib (GSK1120212), in patients with metastatic BRAF-mutant melanoma. 23248257

2013

Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
CUI: C0025202
Disease: melanoma
melanoma
0.670 GeneticVariation BEFREE Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011