Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE Additionally, <b>18e</b> showed an excellent bioavailability (<i>F</i> = 58%), a suitable half-life time (<i>T</i><sub>1/2</sub> = 4.1 h), a satisfactory metabolic stability, and a weak CYP3A4 inhibitory activity, suggesting that <b>18e</b> might be a potential drug candidate for JAK2-driven myeloproliferative neoplasms and FLT3-internal tandem duplication-driven acute myelogenous leukemia. 31670517

2019

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease. 30420889

2018

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE In this study, we used a genetic mouse model to determine whether miR-155 influences the development of FLT3-ITD-induced myeloproliferative disease. 28432220

2017

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE DNMT3A haploinsufficiency results in reversible epigenetic alterations that transform FLT3(ITD)-mutant myeloproliferative neoplasm into AML.Cancer Discov; 6(5); 501-15. 27016502

2016

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE In a FLT3-ITD in vivo model, SYK is indispensable for myeloproliferative disease (MPD) development, and SYK overexpression promotes overt transformation to AML and resistance to FLT3-ITD-targeted therapy. 24525236

2014

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. 25456130

2014

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Kinase inhibition of (mutant) KIT, PDGFR and FLT3 isoforms by quizartinib leads to potent inhibition of cellular proliferation and induction of apoptosis in in vitro leukemia models as well as in native leukemia blasts treated ex vivo. 23497317

2013

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Previous studies have reported FLT3 mutation in as many as 9.2% of myeloproliferative neoplasms (MPNs) and myelodysplastic/myeloproliferative neoplasms (MDS/MPNs), as well as in chronic myelogenous leukemia, that are negative for the JAK2 V617F gene mutation; no FLT3 mutation has been found in JAK2-positive MPNs, suggesting that the mutations are mutually exclusive. 23846442

2013

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE In a murine bone marrow transplantation model, the coexpression of SOCS1 and FLT3-ITD significantly shortened the latency of a myeloproliferative disease compared with FLT3-ITD alone (P < .01). 22517899

2012

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Previous work has shown that insertion of an FLT3/ITD mutation into the murine Flt3 gene induces a myeloproliferative neoplasm, but not progression to acute leukemia, suggesting that additional cooperating events are required. 22323452

2012

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE Reactivation of DEP-1 by stable overexpression of Prx-1 extended survival of mice in the 32D cell/C3H/HeJ mouse model of FLT3 ITD-driven myeloproliferative disease. 22438257

2012

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE Using the c-Cbl RING finger mutant mouse as a model of a myeloproliferative disease (MPD) driven by wild-type Flt3, in the present study, we show that treatment with the Flt3 kinase inhibitor AC220 blocks MPD development by targeting Flt3(+) multipotent progenitors (MPPs). 22990016

2012

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3. 18663058

2008

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. 18245664

2008

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. 17936561

2007

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE A t(12;13)(p13;q12) translocation between Tel and the FLT3 receptor was recently described in a patient with myeloproliferative disease (MPD). 17268528

2007

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Transplantation of wild-type bone marrow cells transduced with the FLT3-ITD gene induced lethal myeloproliferative disease (MPD) in the recipient mice at a median latency of 89 days. 16867903

2006

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE Furthermore, FLT3-ITD-Y589/591F was incapable of inducing a myeloproliferative phenotype when transduced into primary murine bone marrow cells, whereas FLT3-ITD induced myeloproliferative disease with a median latency of 50 days. 16627759

2006

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE Five independent lines of vav-FLT3-ITD transgenic mice developed a myeloproliferative disease with high penetrance and a disease latency of 6-12 months. 16116483

2005

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 GeneticVariation BEFREE These results demonstrate that FLT3-ITD mutant proteins are sufficient to induce a myeloproliferative disorder, but are insufficient to recapitulate the AML phenotype observed in humans. 11756186

2002

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease
0.100 Biomarker BEFREE FLT3-ITDs also induce a myeloproliferative disease in a murine bone marrow transplant model, but are not sufficient to cause AML. 12060771

2002