Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE This review focuses on present knowledge and recent development in the study of heparanase in cancer progression as well as on novel mechanisms by which heparanase regulates tumor metastasis and chemo-resistance. 31348993

2020

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Although cancer cells use heparanase for tumor metastasis, favourable effects of heparanase have been reported in the management of Alzheimer's disease and diabetes. 31004678

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase, an endo-β-D-glucuronidase, cleaves cell surface and extracellular matrix heparan sulfate (HS) chains and plays important roles in cellular growth and metastasis. 30446119

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In summary, metastasis has a predilection to organs with low levels of heparanase, TF, TFPI, and TFPI-2 in the microcirculation, which enables tumor cell retention. 31128083

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In this study, an enzyme-responsive nanoparticle was designed for tumor subtypes with the high expression of heparanase-1, since highly metastatic tumors such as melanoma generally express significant levels of heparanase-1. 31682909

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Thus, our study not only establishes a specific inhibitor of heparanase with high affinity but also illustrates the high effectiveness of this multivalent heparanase inhibitor in inhibiting experimental metastasis in vivo. 30543095

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase has been strongly associated with important pathological processes including inflammatory disease and tumor metastasis, through its ability to promote various cellular functions such as cell migration, invasion, adhesion, and cytokine release. 31110966

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE RNA-sequencing analysis was performed upon knockdown of HPSE, and several pathways were identified that are closely associated with invasion and metastasis. 31001480

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE HPA was related to lymph metastasis and invasive depth.HPA positive GC cases and <i>H. pylori</i> positive GC cases showed poorer prognosis than HPA negative cases (<i>P</i> < 0.05). 30386106

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Both heparanase mRNA and activity in plasma and urine decreased significantly in 17 patients who underwent R<sub>0</sub> resection, but increased remarkably in 6 patients when recurrence or metastasis occurred (P < 0.05). 29153700

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase, the sole heparan sulfate (HS) degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation. 30627323

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase, the sole heparan sulfate (HS) degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation. 29721203

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis. 28916201

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase (HPA) is involved in tissue remodelling and cell migration, which leads to inflammation and tumour metastasis. 30320396

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE We sought to evaluate the feasibility of HPA as a common TAA for magnetic resonance imaging (MRI) of tumor metastasis and its potential application in tumor molecular imaging. 29671088

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE However, the roles of eRNAs in regulating the expression of heparanase (HPSE), an established endo-β-D-glucuronidase essential for cancer invasion and metastasis, still remain elusive. 29511351

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE The up-regulation of heparanase expression increases tumor size, angiogenesis, and metastasis, representing a validated target in the anti-cancer field. 30412404

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Thus, examination of heparanase levels in the tumor metastases should be evaluated for most efficient precision medicine applying heparanase inhibitors. 29464068

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Several dendrimer HS glycomimetics display low nM IC<sub>50</sub> potency for heparanase inhibition equivalent to comparator compounds in clinical development, and potently inhibit metastasis and growth of human myeloma tumor cells in a mouse xenograft model. 30480427

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Our data reveal that heparanase-mediated cell adhesion is critical for metastasis mediated by intravascular CTC clusters. 29417941

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase, the sole heparan sulfate (HS)-degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation. 29162390

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Mammalian cells express a single functional heparanase, an endoglycosidase that cleaves heparan sulfate and thereby promotes tumor metastasis, angiogenesis, and inflammation. 29579286

2018

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Heparanase is a heparan sulfate degrading enzyme that cleaves heparan sulfate (HS) chains present on HS proteoglycans (HSPGs), and has been well characterized for its roles in tumor metastasis and inflammation. 28778449

2017

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE By degrading HS, HPSE not only alters the integrity of the ECM but also releases growth factors and angiogenic factors bound to HS chains, therefore, changes various cellular activities, including cell mobility that is critical for cancer metastasis. 28025251

2017

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE This review focuses on recent developments in the field of heparanase regulation of cancer and inflammation, including the impact of heparanase on exosomes and autophagy, and novel mechanisms whereby heparanase regulates tumor metastasis, angiogenesis and chemoresistance. 27758044

2017