Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Matrix metallopeptidase 2 (MMP-2) and matrix metallopeptidase 9 (MMP-9) are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes, such as cancer metastasis. 31820313

2020

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In ATAT for the group of patients with distant metastasis (M1) the superoxide generation rate, MMP-2, 9 activities are about 2 times higher (p < 0.05) than in the subgroup without distant metastases (M0). 31711773

2020

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Immunohistochemical expression was found for MMP-14 in all primary tumors as well as in all metastases and for MMP-2 expression in most of the samples. 30741846

2020

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE MMP2 is a downstream effector that influences the metastasis seen with uveal melanoma cells. 31661551

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Our results showed, reduction in MMP-2 (p=0.08), MMP-9 (p=0.03), CCL22 (p=0.003) and TGFβ1 (p=0.1) gene expression and Tregs frequency (p=0.01) which play a main role in the development of chronic inflammation, angiogenesis, tumorigenesis and metastasis. 30848576

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Thymoquinone inhibits metastasis of renal cell carcinoma cell 786-O-SI3 associating with downregulation of MMP-2 and u-PA and suppression of PI3K/Src signaling. 31217736

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Western blotting results revealed that knocking down ZEB2-AS1 could inhibit cell invasion and metastasis by suppressing the epithelial to mesenchymal transition (EMT) as well as the expressions of matrix metallopeptidase-2 (MMP-2) and MMP-9 in AGS cells. 31128021

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE MMP2 plays an important role in the metastasis of cancer cells. 30352219

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Therefore, our findings suggest that MIF may promote the invasion and metastasis of OSCC through the activation of MMP-2 and MMP-9 and prompt further investigation into the therapeutic value of MIF for OSCC treatment. 31219646

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE <b>Conclusion:</b><i>WFDC2</i> contributed to ovarian cancer metastasis and EMT as a positive regulator by activating AKT signaling pathway and inducing MMP-2 expression. 31118763

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE This induced the expression of metastasis‑associated genes, including C‑X‑C chemokine receptor 4, matrix metalloproteinase (MMP)1 and MMP2. 31485630

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE The experiments further demonstrated that SPG-56 inhibited the metastasis of breast cancer in MCF-7 and 4T1-bearing mice by altering the expression of MMP2, MMP9, VEGF, Occludin and Claudin. 30651572

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Furthermore, the down-regulation of matrix metalloprotein 2 (MMP2) and MMP9 also reduce the rate of tumor metastasis. 31136911

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis. 31243109

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE T-MAN displays a high r<sub>1</sub> relaxivity (∼60.0 mM<sup>-1</sup> s<sup>-1</sup> per Gd<sup>3+</sup> at 1 T) and a large near-infrared (NIR) fluorescence turn-on ratio (∼185-fold) in response to MMP-2, allowing high-spatial-resolution magnetic resonance imaging (MRI) and low-background fluorescence imaging of gastric tumors as well as lymph node (LN) metastasis in living mice. 30688465

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Activation of pancreatic stellate cells may promote the expression of MMP2 and enhance the invasion and metastasis of pancreatic carcinoma. 30466735

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE MPPa-PDT downregulated the expression of MMP2 and MMP9, which are responsible for the initiation of metastasis. 31783821

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The effect of tomatidine on the inhibition of matrix metalloproteinase-2 (MMP-2) and MMP-9, gelatinases related to metastasis, was analyzed using gelatin zymography, western blot and immunofluorescence staining. 31545954

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Melanoma metastasis requires migration and invasion of the malignant tumour cells driven by proteolytic remodelling of the extracellular matrix (ECM) executed by matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9. 31020875

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In summary, our study revealed a novel mechanism of the RBMS3/Twsit1/MMP2 axis in the regulation of invasion and metastasis of breast cancer, which may become a potential molecular marker for breast cancer treatment. 30819235

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In an analysis of the miRNA target genes, we found that CDH2, KNG1, and MMP2 were correlated with CRC metastasis. 30807603

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are upregulated in most cancers and play crucial roles in modulating invasion and metastasis. 30074136

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The identification of the miR-146b/AUF1/ETS2/MMP2 mechanism for promoting bladder cancer invasion provides significant insights into understanding the nature of bladder cancer metastasis. 31071529

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Therefore, the DSTYK mutation may activate ERK1/2/MMP2/9 signaling to promote tumor cell metastasis in SFT/HPC. 31201369

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE IHC analysis revealed that a high expression of <i>UCA1</i> was accompanied by a high expression of metastasis-related proteins (MMP-2 and MMP-9), thereby validating the correlation of <i>UCA1</i> expression with metastasis. 30863094

2019