Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker BEFREE Percutaneous biopsy of a newly identified suspected lesion in the fifth thoracic vertebra revealed a metastasis with positive staining for ACTH, synaptophysin and chromogranin A. 31640675

2019

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker BEFREE Merely 2% of BCTs secrete ACTH and less than 1% of patients with Cushing's syndrome (CS) have a BCT.Typical BCTs rarely metastasize. 28449502

2017

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker BEFREE Together, these results indicate that HDGF downregulation participates in POMC-induced suppression of metastasis and EMT in melanoma. 23468531

2013

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker BEFREE Our previous studies have indicated that POMC gene delivery inhibited the progression and metastasis of B16-F10 melanoma via the α- melanocyte-stimulating hormone/melanortin-1 receptor (MC-1R) pathway. 22147647

2012

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 AlteredExpression BEFREE This is the first case of Cushing's syndrome secondary to ectopic ACTH secretion where the presence of ACTH by immunohistochemistry and the expression of the POMC gene by RT-PCR have both been demonstrated in a breast carcinoma with metastases. 15239795

2005

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 AlteredExpression BEFREE Abnormal NPP expression is involved in pathological mineralization, crystal depositions in joints, invasion and metastasis of cancer cells, and type 2 diabetes. 12757929

2003

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 GeneticVariation BEFREE Overall, pituitary carcinoma metastases showed an average of 8.3 chromosomal imbalances per tumor (7 gains vs 1.3 losses), 10 in prolactin cell carcinoma metastases (7.5 gains vs 2.5 losses) and 6.5 in ACTH cell carcinoma metastases (6.5 gains vs 0 loss). 11563625

2001

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker BEFREE The length of POMC mRNA in MTCs (present in all 4 metastases investigated but not in 7 primary tumors) and pheochromocytomas is about 100 nucleotides more than pituitary POMC RNA. 3488930

1986

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.090 Biomarker BEFREE Compared with the POMC mRNA occurring in the human pituitary gland, the size of the RNA species hybridizing to the POMC-specific probe was larger in the metastases of both of the patients investigated. cDNA complementary to mRNA from one of the metastases was cloned into pBR 322. 6546764

1984