Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis. 28865485

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE Also, G allele carriers of COX-2 were associated with metastatic cancer (OR = 1.3, P < 0.05) and disease aggressiveness (OR = 3.5, P < 0.001). 26920155

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In addition, Cox regression model, revealed that metastasis (p= 0.014), tumor site (p= 0.013), histotype (p = 0.02), and COX-2 expression (p = 0.003) are independent factors for prognosis. 27314294

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE COX-2 overexpression significantly enhanced migration and invasion of SP cells, while reducing expression of metastasis-related proteins PDCD4 and PTEN. 26554780

2016

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In summary, Berberin inhibited CRC invasion and metastasis via down-regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway. 25954974

2016

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In melanoma, Cox-2 is over expressed in primary malignant melanoma (MM) and in their corresponding metastases. 25060715

2016

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Therefore, the results suggest that proton beam irradiation inhibited the cancer cell growth and metastasis associated with COX-2 and MMP-9 expression in MDA-MB‑231 human breast cancer cells, and that the antimetastatic effect of proton beam irradiation is achieved by the suppression of NF-κB phosphorylation via inhibition of Akt activation. 24859472

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE COX-2 upregulation was associated with downregulation of KAI-1/CD82, a metastasis suppressor molecule that has been associated with the metastatic potential of several solid tumors. 23617728

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Co-expression of cancer COX-2 and stromal IDO predicts a worse disease-free and metastasis-free survival. 25060643

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Univariate analysis showed that COX-2 protein expression was associated with shorter disease-free survival (DFS) (P = 0.0001), metastasis-free survival (MFS) (P = 0.002) as well as breast cancer specific overall survival (OS) (P = 0.043). 25511800

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Elevated expression of cyclooxygenase-2 (COX-2) is observed in many human cancers and over-production of downstream prostaglandins (PGs) has been shown to stimulate metastasis. 26067757

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In PC-3 cells, INPP4B overexpression caused a decline in the level of metastases associated BIRC5 protein, phosphorylation of PKC, and expression of the common PKC and IL-8 downstream target, COX-2. 25248616

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Our studies also suggested a new approach to inhibit STIM1-mediated metastasis with COX-2 inhibitors. 25381814

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Taken together, the results obtained here demonstrated that i) CBDA had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and ii) CBDA may possess the ability to suppress genes that are positively involved in the metastasis of cancer cells in vitro. 25242400

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) are two highly expressed inflammatory mediators to be induced by the protein kinase C (PKC) signaling via various inflammatory stimuli and both contribute significantly to cancer metastasis/progression. 25754990

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Hu-antigen R (HuR) is considered to play a central role in tumor formation, growth, and metastasis by binding to messenger RNAs (mRNAs) encoding proteins such as cyclooxygenase-2 (COX-2) and inducing their expression via mRNA stabilization and/or altered translation. 25252849

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE There are seven categories of molecules known to correlate with the response and/or prognosis: tumor suppressors (p53, p21), cell cycle regulators (Cyclin D1, CDC25B, 14-3-3sigma), DNA repair molecules (p53R2, ERCC1), drug resistance proteins [metallothionein (MT)], angiogenic factors (VEGF), molecules involved in cell proliferation/invasion/metastasis (Ki-67, COX-2) and hedgehog signaling molecules (Gli-1). 23605218

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE COX-2 may play a pivotal part in the maintenance of tumor viability, growth, and metastasis. 24533777

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE It is found that LV-COX-2 combination with TAM treatment in breast cancer cell significantly suppressed the proliferation and metastasis, and induced tumor apoptosis in vitro, and tumor growth also was suppressed in vivo. 24535190

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression. 23922175

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Also, transcription of TPA-induced cyclooxygenase-2 (COX-2), which enhances breast cancer progression and metastasis via the increase of prostaglandin E2 biosynthesis, was downregulated by the PS in a dose-dependent manner. 24065532

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Cyclooxygenase-2 (COX-2) participates in cancer invasion and metastasis by decreasing the expression of E-cadherin. 23670240

2013

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Correlations between the expression of COX-2 with tumor growth and distant metastasis have become an issue; thus, attention has been paid to COX-2 as a prognostic factor. 23527044

2013

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE In vivo apricoxib combination therapy was only effective at reducing tumor growth and metastasis in tumors with elevated COX-2 activity. 22829202

2013

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Taken together, our study reveals the diverse impacts of Cox-2 inhibitors on EMT in NSCLC cells independent of Cox-2 inhibition, where celecoxib treatment leads to metastasis and chemoresistance via EMT induction. 23172668

2013