Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In-vivo evaluation over 16 week DMBA/croton oil tumor induced mice model showed noteworthy tumor targeting with down regulation of overexpressed COX-2, cytokines and nuclear factors on western blot analysis. 31761163

2020

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE This finding was accompanied with upregulated pro-inflammatory factors IL-6, TNFα, COX2 and NOS2 in tumors of Par2<sup>-/-</sup> mice. 31733286

2020

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE COX-2 is frequently overexpressed in tumors and increases tumor invasiveness and angiogenesis. 30715649

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE COX-2 expression was only significantly correlated with the tumor stage. 30638861

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE TPA is considered to be a tumor promoting molecule that induces the expression of COX-2 protein. 30641217

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The co-expression of PTGS2 gene and M2 markers in human thyroid carcinoma highlights the possibility to counteract tumor growth through COX-2 inhibition. 31113465

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In this study, we have further investigated the anti-tumor effects of D5D-knockdown and the resulting intensified COX-2-catalyzed DGLA peroxidation in subcutaneous xenograft tumors. 30384258

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE High levels of expression of both SCF& COX-2 are associated with higher incidence of tumor relapse, worse disease overall survival and free survival (p < 0.001). 30402808

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 GeneticVariation BEFREE There was an elevated expression of the immunosuppressive genes PTGS2 (encoding COX-2) and CD274 (encoding PD-L1) in human and murine claudin-low tumors. 31366361

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE COX-2 and proliferating cell nuclear antigen (PCNA) expression were assessed immunohistochemically. lncRNA-CCHE1 expression was upregulated in CRC tissues compared to adjacent non-cancerous tissues, and was significantly associated with larger tumor size, less differentiated histology, advanced dukes' stage, positive lymph node involvement and vascular invasion. 30484108

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In addition, it reduced post-in vitro proliferation and suppression of tumor growth by inducing the expression of caspase-3 and phospho-H2A.X (Ser139) while reducing the expression of COX-2 in both murine cancer models. 31092422

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Moreover, both positive COX2 expression and anterior wall tumor subsite were independently correlated with lymph node metastasis, which was the only independent prognostic factor in p16-positive OPSCC. 31570459

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE COX-2 expression was significantly higher among B-Raf proto-oncogene, serine/threonine kinase, mutant (BRAF<sup>mut</sup>) tumors. 31614548

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Because the association between T cell infiltration and the EPHA2/TGF-β/COX-2 axis is supported by independent clinical data, these results provide a rationale for ensuing clinical trials aimed at incorporating pancreatic cancer into the range of immunotherapy-responsive tumors. 31355777

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In MCF-7/ADR tumor-bearing nude mice, HPPDC nanoparticles showed excellent tumor-targeting ability, remarkably enhanced tumor chemosensitivity and reduced COX-2 and P-gp expressions in tumor tissues. 31623608

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In the present study, we reported the first case of HPGD mutated PHO patient with soft tissue giant tumors at lower legs and evaluated the efficacy of selective COX-2 inhibitor (Etorcoxib) treatment in the patient. 31063976

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Tumor-supplied IL1β contributes to adipocyte lipolysis and regulates a proinflammatory phenotype in adipocytes via upregulation of COX-2 and MCP-1. 31562254

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE COX-2 is released by cancer-associated fibroblasts (CAFs), macrophage type 2 (M2) cells, and cancer cells to the tumor microenvironment (TME). 30341914

2019

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Furthermore, VRCZ per se stimulates aryl hydrocarbon receptor (AhR) and upregulates COX-2, which is a pivotal enzyme for the promotion of UV-associated tumors, in an AhR-ARNT dependent manner of the classical (genomic) pathway. 29568008

2018

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE COX2 overexpression is predictive of pCR in patients with celecoxib-treated tumors. 29491076

2018

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients. 28808873

2018

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Furthermore, low levels of stromal TRIM28 correlated with elevated MDM2 levels in tumor epithelium (p = 0.01) and COX-2 levels in tumor stroma (p = 0.002). 29631612

2018

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Expression of CYP19A1 (aromatase) was significantly correlated with COX2, but only in tumors positive for ER, PR and HER2. 29736687

2018

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE This is the first study which separately analyzes peritumoral stroma and tumor core area in laryngeal squamous cell carcinoma in terms of CD45, CD11b, CD3, MMP-9 and COX-2 expression. 29492204

2018

Entrez Id: 4513
Gene Symbol: COX2
COX2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In contrast, tumor tissues increased the CD31-immunoreactive endothelial cell area, and accumulated stromal cells immunoreactive for COX-2 and tumor cell population immunoreactive for inducible nitric oxide synthase. 29520973

2018