Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE VDR KO did not alter Nos2 mRNA levels but significantly increased Arg1 mRNA levels in tumor M-MDSC by 100 %. 31783150

2020

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Here we show by immunohistochemistry and RNAscope in situ hybridization that vitamin D receptor (VDR) is unexpectedly expressed in LGR5<sup>+</sup> colon stem cells in human tissue and in normal and tumor organoid cultures generated from patient biopsies. 31306552

2020

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Further investigation revealed that compound 28 inhibited tumor growth in an orthotopic breast-tumor model without causing hypercalcemia which is the main side effect of secosteroidal VDR modulators. 30579121

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Vitamin D receptor in NF1-tumors was examined by means of immunohistochemistry using an antibody against the vitamin D1 receptor. 30299316

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE When assessed by a priori defined functional pathways, tumor growth factor β (TGFβ) signaling was associated with CRC risk (<i>P</i> ≤ 0.001), with most statistically significant genes being <i>SMAD7 (P<sub>BH</sub></i> = 0.008) and <i>SMAD3 (P<sub>BH</sub></i> = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (<i>P</i> = 0.036). 31434255

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE The Tumor Suppressor FBW7 and the Vitamin D Receptor Are Mutual Cofactors in Protein Turnover and Transcriptional Regulation. 30606768

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE We found that positive VDR expression in the nuclei and cytoplasm of breast cancer cells was associated with favorable tumor characteristics such as smaller size, lower grade, estrogen receptor positivity and progesterone receptor positivity, and lower expression of Ki67. 31358030

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Vitamin D3 is known to have anticancer actions by affecting tumorigenesis including the cell cycle and cell apoptosis in gastric cancer (GC) cells; the genes including microRNAs (miRNAs) regulated by vitamin D3 signaling remain discovered. miR-99b-3p, the tumor suppressor gene, is not only decreased in GC tissues, but is also induced by vitamin D3 through the vitamin D receptor (VDR) binding on the promoter domain of miR-99b. 31287793

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Loss of the VDR in human breast cancer cells marks a critical point in oncogenesis by inducing EMT, promoting the dissemination of cancer cells, and facilitating the formation of tumor colonies in bone. 30995345

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE JNK1 and VDR act as tumor suppressors, and their stromal expression levels are associated with prognosis in esophageal squamous cell carcinoma. 29423673

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Furthermore, high MAPK activity in tumours expressing cytoplasmic VDR was associated with worsened prognosis. 30004989

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Loss of cytoplasmic VDR was associated with melanoma tumour size, suggesting that loss of cytoplasmic VDR may be a prognostic factor. 29106699

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE The vitamin D receptor (VDR) is expressed in the tumor stroma and treatment with VDR ligands results in stromal remodeling and increased intratumoral gemcitabine delivery. 30299542

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Taken together, these findings confirmed that VDR functions as a tumour suppressor in RCC cells and suppresses the proliferation, migration and invasion of RCC through regulating the expression of TRPV5. 29659618

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Tissue microarrays were created and immunohistochemical staining for VDR was performed on triplicate tumour cores from each resection specimen. 30344947

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Model systems of carcinogenesis have provided evidence that both VDR expression and 1,25D actions change with transformation but clinical data regarding vitamin D responsiveness of established tumors is limited and inconclusive. 28746837

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Here we review our recent findings in this area, including our data revealing that reduction of the expression of the vitamin D receptor (Vdr) within BCa cells accelerates primary tumor growth and enables the development of metastases, demonstrating a tumor autonomous effect of vitamin D signaling to suppress BCa metastases. 28710021

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Although the compounds induced hypercalcemia at elevated doses, consistent with VDR agonism in vivo, they both reduced tumor burden at doses below their MTD's. 28847749

2018

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Recent findings convincingly support the concept of a new function of the VDR as a tumor suppressor in skin, with key components of the vitamin D endocrine system, including VDR, CYP24A1, CYP27A1, and CYP27B1 being strongly expressed in non-melanoma skin cancer (NMSC). 28526240

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE PR, but not VDR, mRNA expression was significantly associated with the tumor size (r = 0.645, p = 0.007). 28589382

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE In the intra-tibial xenograft model, VDR knockdown greatly reduced the ability of the cells to form tumors in the bone microenvironment. 28460457

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation <i>in vitro.</i> Implantation of these VDR knockdown cells into the mammary fat pad (MDA-MB-231), subcutaneously (PC3) or intra-tibially (both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls. 28944088

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation BEFREE Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status. 29434472

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation BEFREE Vitamin D receptor (VDR) polymorphisms are found more commonly in some tumor types than in healthy individuals, suggesting that some polymorphisms (Cdx2, Fok1, Bsm1, Apa1, Taq1) contribute to tumor development. 27606438

2017

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE High VDR expression in tumour stromal fibroblasts was associated with better overall survival (OS) and progression-free survival in CRC, independently of its expression in carcinoma cells. 27053631

2017