Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker BEFREE Concomitant neutralization of IFN-γ and IL-6 significantly reduced the degree of pneumonia as well as bacteremia compared to the control group, indicating a positive effect for the host during secondary bacterial infection. 31474978

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 AlteredExpression BEFREE Our in vivo results demonstrated that Gln treatment reduced ET release (as indicated by cell-free-DNA content and myeloperoxidase activity), decreased lung inflammation (reductions in interferon-γ and increases in interleukin-10 levels), and improved lung morpho-function (decreased static lung elastance and alveolar collapse) in comparison with ARDS animals treated with saline. 31013737

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker BEFREE These data identified Ly6C+ CD8+ T lymphocytes as a source of IFN-γ in innate immunity and partially associated with reduced IFN-γ production, M2 polarization, and high mortality in anti-Gr-1 antibody-treated mice with L. pneumophila pneumonia. 30021216

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 AlteredExpression BEFREE After treatment for 120 h, the D-dimer and INF-γ levels in both pneumonia groups were lower than those before treatment (p<0.001). 30546408

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker BEFREE Notably, sensitization of IL-10-deficient mice with OVA/Alum/CpG resulted in the development of neutrophilic lung inflammation associated with IFNγ production. 28220116

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 AlteredExpression BEFREE We demonstrate that KB treatment attenuated cigarette smoke-induced lung inflammation as shown by reductions in levels of BAL IFNγ, CXCL9, CXCL10, CCL5, IL-6, G-CSF, and IL-17. 28506308

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker BEFREE The serum concentrations of tumor necrosis factor alpha (median 114.5 pg/ml, range 49.1-897.9 pg/ml) and interferon gamma (median 376.9 pg/ml, range 221.4-1997.6 pg/ml) were significantly higher in children with RMPP compared to children with NRMPP. 25449230

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 GeneticVariation BEFREE Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis. 24475220

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker BEFREE Pulmonary inflammation in mice with collagen-induced arthritis is conditioned by complete Freund's adjuvant and regulated by endogenous IFN-γ. 22930199

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 Biomarker BEFREE Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. 21967766

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 AlteredExpression BEFREE IFN-γ mRNA levels were reduced in the pneumonia group (2.48; 1.20-3.20) compared with nonpneumonia group (2.81; 2.10-3.26) (P=03) day 5 postsurgery. 20829336

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.400 AlteredExpression BEFREE The fatal lung inflammation is associated with high-level induction of interferon-gamma and its inducible inflammatory chemokines, suggesting the involvement of a T-helper-1 immune response. 20363924

2010